Stricture prevention after circumferential endoscopic submucosal dissection of the esophagus: Proactive vs reactive strategies

doi:10.4253/wjge.v17.i3.101428

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Mar 16, 2025 (publication date) through Mar 14, 2025

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Mar 16, 2025; 17(3): 101428
Published online Mar 16, 2025. doi: 10.4253/wjge.v17.i3.101428

Stricture prevention after circumferential endoscopic submucosal dissection of the esophagus: Proactive vs reactive strategies

Giulio Calabrese, Sandro Sferrazza, Daryl Ramai, Marcello Maida

Giulio Calabrese, Sandro Sferrazza, Department of Gastroenterology and Endoscopy, ARNAS Ospedali Civico-Di Cristina-Benfratelli, Palermo 90127, Sicilia, Italy

Daryl Ramai, Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Boston, MA 02115, United States

Marcello Maida, Department of Medicine and Surgery, University of Enna “Kore,” Enna 94100, Sicilia, Italy

Author contributions: Calabrese G, Sferrazza S, Ramai D, and Maida M are the guarantors of the integrity of the entire study and contributed to the manuscript drafting and revision for important intellectual content.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Marcello Maida, MD, Associate Professor, Department of Medicine and Surgery, University of Enna “Kore,” Via Cusmano, 1, Enna 94100, Sicilia, Italy. marcello.maida@unikore.it

Received: September 14, 2024
Revised: December 30, 2024
Accepted: February 10, 2025
Published online: March 16, 2025
Processing time: 181 Days and 10.5 Hours

Core Tip

Core Tip: This editorial displayed the current strategies for preventing stenosis formation after circumferential esophageal endoscopic submucosal dissection. Use of a single reactive or proactive strategy has not been found to be highly effective, especially in resections involving the entire esophageal circumference. Combining two or more strategies represents a promising option to optimize patients’ quality of life and reduce symptoms. As a result, there is a pressing need for large prospective studies to further investigate this issue and ultimately determine the most effective strategy.