Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Feb 16, 2025; 17(2): 102532
Published online Feb 16, 2025. doi: 10.4253/wjge.v17.i2.102532
Clinical impact of endoscopy in severely thrombocytopenic patients with hematologic malignancy experiencing gastrointestinal bleeding
Badr Alhumayyd, Ashton Naumann, Amanda Cashen, Chien-Huan Chen
Badr Alhumayyd, Department of Gastroenterology, King Saud University, Riyadh 22480, Ar-Riyāḍ, Saudi Arabia
Ashton Naumann, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States
Amanda Cashen, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States
Chien-Huan Chen, Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States
Author contributions: Alhumayyd B collected and analyzed the data, wrote the sections related to material and methods, statistical analysis and results along with editing and reviewing the manuscript; Naumann A contributed to writing and editing the manuscript; Cashen A contributed to the research methodology along with reviewing the manuscript; Chen CH reviewed the data and edited the manuscript for the final approval.
Institutional review board statement: This study was approved by the Washington University in St. Louis Institutional Review Board.
Informed consent statement: This project has been granted a waiver of HIPAA Authorization per section 164.512(i) of the Privacy Rule to allow the research team to use Protected Health Information (PHI) in the context of this research study. This determination is based on the documentation provided by the researcher in the IRB application and the assurance document signed by the Principal Investigator.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at balhumayyd@gmail.com. The presented data are anonymized with no risk of identification.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Badr Alhumayyd, MD, Assistant Professor, Department of Gastroenterology, King Saud University, 11495 King Abdulla Street, Riyadh 22480, Ar-Riyāḍ, Saudi Arabia. balhumayyd@gmail.com
Received: October 21, 2024
Revised: December 26, 2024
Accepted: January 14, 2025
Published online: February 16, 2025
Processing time: 115 Days and 5.9 Hours
Core Tip

Core Tip: Hematologic malignancies have a higher risk of diffuse gastrointestinal bleeding (GIB) related to severe thrombocytopenia and platelet dysfunction. It is unclear if endoscopy impacts the management of these patients. In this study, we investigated whether endoscopy improved the outcome of patients with hematologic malignancy and severe thrombocytopenia who experienced acute overt GIB compared to conservative management. Our results show no statistical difference in mortality, recurrent bleeding and length of stay between endoscopic and conservative management. However, endoscopy within 24 hours of GIB significantly reduced the 30-day recurrent bleeding rate compared to endoscopy performed > 24 hours.