Randomized Clinical Trial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Feb 16, 2025; 17(2): 100722
Published online Feb 16, 2025. doi: 10.4253/wjge.v17.i2.100722
Effect of etomidate added to propofol target-controlled infusion in bidirectional endoscopy: A randomized clinical trial
Hui-Rong Luo, An-Di Chen, Jing-Fang Lin, Peng Ye, Ying-Jie Chen, Ming-Xue Lin, Pin-Zhong Chen, Xiao-Hui Chen, Xiao-Chun Zheng
Hui-Rong Luo, Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China
An-Di Chen, Jing-Fang Lin, Peng Ye, Ying-Jie Chen, Ming-Xue Lin, Pin-Zhong Chen, Xiao-Hui Chen, Xiao-Chun Zheng, Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350000, Fujian Province, China
Author contributions: Luo HR contributed to study conception, design, data collection and write the manuscript; Chen AD contributed to data collection and write the manuscript; Lin JF contributed to implementation of clinical anesthesia and the revision of the manuscript; Ye P, Chen YJ, Lin MX and Chen PZ contributed to data collection; Chen XH contributed to study design, supervised the work, performed the analysis, contributed data and analysis tools; Zheng XC contributed to study design, revised the manuscript; All authors made critical revisions and approved the final version to be published. Luo HR and Chen AD contributed equally to this work as co-first authors; Chen XH and Zheng XC contributed equally to this work as co-corresponding authors. The reasons for designating Chen XH and Zheng XC as co-corresponding authors are that Zheng XC is responsible for coordination and quality control; Chen XH is responsible for design of the project.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Boards of Fujian Provincial Hospital of Fujian Medical University (Approval No. K2021-05-036).
Clinical trial registration statement: This study is registered at https://www.chictr.org.cn/searchproj.html. The registration identification number is ChiCTR2100044884.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: Consent was not obtained but the presented data are anonymized and risk of identification is low.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Hui Chen, MD, Chief Physician, Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, No. 134 East Street, Fuzhou 350000, Fujian Province, China. chenxh@fjmu.edu.cn
Received: August 28, 2024
Revised: January 6, 2025
Accepted: January 18, 2025
Published online: February 16, 2025
Processing time: 169 Days and 11.3 Hours
Core Tip

Core Tip: This randomized controlled trial compared the effect of different dose etomidate added to propofol target-controlled infusion (TCI) sedation in 330 patients during same-visit bidirectional endoscopy. Adding 0.15 mg/kg etomidate to propofol TCI during endoscopy reduces incidence of hypotension, injection pain, and respiratory depression while improving satisfaction among patients, endoscopists, and anesthesiologists. There was no difference in the adverse events among three groups.