Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Aug 16, 2024; 16(8): 462-471
Published online Aug 16, 2024. doi: 10.4253/wjge.v16.i8.462
Effectiveness of serological markers of gastric mucosal atrophy in the gastric precancer screening and in cancer prevention
Sergey M Kotelevets, Sergey A Chekh, Sergey Z Chukov
Sergey M Kotelevets, Department of Therapy, North Caucasus State Academy, Cherkessk 369000, Karachay-Cherkess Republic, Russia
Sergey A Chekh, Department of Mathematics, North Caucasus State Academy, Cherkessk 369000, Karachay-Cherkess Republic, Russia
Sergey Z Chukov, Department of Pathological Anatomy, Stavropol State Medical University, Stavropol 355017, Russia
Author contributions: Kotelevets SM and Chekh SA designed the study; Kotelevets SM performed the research, and wrote the paper; Chekh SA performed the statistical processing; Chukov SZ performed the histological research and biopsy assessment; Chekh SA and Chukov SZ revised the manuscript for final submission.
Institutional review board statement: The Institutional Review Board provided approval for this study (IRB No. 20/23, 2023 October 16).
Informed consent statement: All patients provided informed written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sergey M Kotelevets, MD, Associate Professor, Department of Therapy, North Caucasus State Academy, Lenina Street, 75/32, Cherkessk 369000, Karachay-Cherkess Republic, Russia. smkotelevets@mail.ru
Received: March 13, 2024
Revised: June 30, 2024
Accepted: July 25, 2024
Published online: August 16, 2024
Processing time: 141 Days and 10.4 Hours
Core Tip

Core Tip: A new assessment of serological markers of atrophic gastritis has been developed and confirmed with application of the updated Kimura-Takemoto morphological classification system. Serological markers of atrophic gastritis in this new interpretation of the classification system can more accurately detect atrophy of the gastric mucosa and complementarily increase the effectiveness of previous technologies for serological screening of precancerous changes in the stomach. Ultimately, this new model of serological screening is highly sensitive for detecting atrophic gastritis across mild, moderate and severe degrees of disease progression.