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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. May 16, 2024; 16(5): 259-272
Published online May 16, 2024. doi: 10.4253/wjge.v16.i5.259
Published online May 16, 2024. doi: 10.4253/wjge.v16.i5.259
Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution: Prospective single-centre trial
Yuan Gao, Lian-Song Ye, Jia Xie, Jiang Du, Qiong-Ying Zhang, Bing Hu, Department of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu 610041, Sichuan Province, China
Xu Li, Center of Biostatistics, Design, Measurement and Evaluation (CBDME), Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Bin Yu, Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu 610065, Sichuan Province, China
Bin Yu, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610044, Sichuan Province, China
Ke Liao, Precision Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Author contributions: Ye LS and Hu B designed the research; Gao Y, Ke Liao, Xie J, Du J and Zhang QY performed the research and collected the data; Gao Y and Li X analyzed the data and drafted the manuscript; Ye LS, Zhang QY, and Hu B revised the manuscript; All authors performed acquisition of data, contributed to the article, and approved the submitted manuscript.
Supported by the 1-3-5 Project for Disciplines of Excellence-Clinical Research Incubation Project , West China Hospital, Sichuan University, No. 2020HXFH016; and the Med-X Innovation Programme of Med-X Center for Materials , Sichuan University, No. MCM202302.
Institutional review board statement: The study protocol was approved by the Biomedical Research Ethics Committee, West China Hospital of Sichuan University (No. HX-IRB-AF-03-V3.0).
Clinical trial registration statement: This registration policy applies to prospective, controlled trials. The protocol was registered at https://www.chictr.org.cn/showproj.html?proj%20=%204134, registration identifier: ChiCTR1900024686.
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: Randomization was not performed in this study, so the manuscript was prepared and revised according to the TREND (transparent reporting of evaluations with nonrandomized designs) statement. The TREND statement has a 22-item checklist Cdc-pdf specifically developed to guide standardized reporting of nonrandomized controlled trials. The TREND statement complements the widely adopted Consolidated Standards Of Reporting Trials (CONSORT) statement developed for randomized controlled trials.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Hu, MD, Professor, Department of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. hubing@wchscu.edu.cn
Received: February 5, 2024
Revised: March 12, 2024
Accepted: April 22, 2024
Published online: May 16, 2024
Processing time: 98 Days and 23.6 Hours
Revised: March 12, 2024
Accepted: April 22, 2024
Published online: May 16, 2024
Processing time: 98 Days and 23.6 Hours
Core Tip
Core Tip: Esophageal lesions stained lightly with iodine solution may progress pathologically even though they have a relatively better prognosis. Vinegar was thought to have an antitumor effect according to previous studies. However, its effect on lesion progression is still unclear. In the present study, we reported that moderate vinegar consumption improved the prognosis of several esophageal lesions lightly stained with Lugol’s iodine solution at a tertiary referral endoscopy centre in China.