Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. May 16, 2023; 15(5): 407-419
Published online May 16, 2023. doi: 10.4253/wjge.v15.i5.407
Diagnostic role of fractional exhaled nitric oxide in pediatric eosinophilic esophagitis, relationship with gastric and duodenal eosinophils
Panamdeep Kaur, Rachel Chevalier, Craig Friesen, Jamie Ryan, Ashley Sherman, Stephanie Page
Panamdeep Kaur, Department of Pediatric Gastroenterology, Connecticut Children’s Medical Center, University of Connecticut School of Medicine, Hartford, Connecticut, CT 06106, United States
Rachel Chevalier, Craig Friesen, Jamie Ryan, Department of Pediatric Gastroenterology, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, MO 64108, United States
Rachel Chevalier, Craig Friesen, Department of Pediatrics, University of Kansas School of Medicine, Kansas City, Kansas, KS 66160, United States
Ashley Sherman, Department of Biostatistics, Children's Mercy Kansas City, Kansas City, Missouri, MO 64108, United States
Stephanie Page, Department of Pediatric Gastroenterology, Midwest Pediatric Specialists, Overland Park, Kansas, KS 66215, United States
Author contributions: Kaur P modified the study design, collected, analyzed and interpreted the data, wrote and revised the manuscript; Chevalier R modified the study design, collected, analyzed and interpreted the data, wrote and revised the manuscript; Friesen C modified the study design, analyzed and interpreted the data, edited and revised the manuscript; Ryan J interpreted the data and edited the manuscript; Sherman A interpreted data, performed statistical analysis of the data and revised analysis and manuscript; Page S designed and performed the research study, interpreted the data and edited the manuscript; All authors have approved the manuscript.
Institutional review board statement: The study was reviewed and approved by the Children’s Mercy Institutional Review Board (Approval No. 11120665).
Informed consent statement: Informed consent was obtained from patients/caregivers prior to enrollment into the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Panamdeep Kaur, MD, Assistant Professor, Department of Pediatric Gastroenterology, Connecticut Children’s Medical Center, University of Connecticut School of Medicine, 282 Washington Street, Hartford, Connecticut, CT 06106, United States. dr.panam.chd@gmail.com
Received: October 2, 2022
Peer-review started: October 2, 2022
First decision: December 1, 2022
Revised: February 5, 2023
Accepted: April 4, 2023
Article in press: April 4, 2023
Published online: May 16, 2023
Processing time: 226 Days and 7.6 Hours
Core Tip

Core Tip: Multiple endoscopies are required as a part of diagnosis and surveillance in pediatric eosinophilic esophagitis (EoE). We assessed fractional exhaled nitric oxide (FeNO)’s role as a non-invasive marker to aid in management of EoE. FeNO may have a role in a subset of pediatric EoE patients to indicate response to therapy. This could potentially be used as an adjunct in pediatric EoE.