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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Mar 16, 2023; 15(3): 84-102
Published online Mar 16, 2023. doi: 10.4253/wjge.v15.i3.84
Gastroesophageal reflux disease in children: What’s new right now?
Palittiya Sintusek, Mohamed Mutalib, Nikhil Thapar
Palittiya Sintusek, Thai Pediatric Gastroenterology, Hepatology and Immunology Research Unit (TPGHAI), Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital and Thai Red Cross, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Bangkok, Thailand
Mohamed Mutalib, Department of Paediatric Gastroenterology, Pediatric and Gastroenterology Services, Evelina London Children’s Hospital, London SE1 7EH, United Kingdom
Nikhil Thapar, Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, Brisbane, Queensland 4101, Australia
Nikhil Thapar, School of Medicine, University of Queensland, Brisbane, Queensland 4006, Australia
Nikhil Thapar, Woolworths Centre for Child Nutrition Research, Queensland University of Technology, Brisbane, Queensland 4101, Australia
Author contributions: Thapar N, Mutalib M, and Sintusek P contributed to conception of the study; Sintusek P drafted the manuscript; Sintusek P and Mutalib M wrote the manuscript; Thapar N made critical revisions related to the intellectual content of the manuscript; all authors read and approved the final version of the manuscript.
Supported by the Research Grant Contract Allocated for Basic Research from the Chulalongkorn University, No. HEA663000047.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nikhil Thapar, FRCP, MRCP, PhD, Professor, Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, 501 Stanley Street, Brisbane QLD 4101, Queensland, Australia. nikhil.thapar@health.qld.gov.au
Received: October 27, 2022
Peer-review started: October 27, 2022
First decision: December 12, 2022
Revised: January 15, 2023
Accepted: February 8, 2023
Article in press: February 8, 2023
Published online: March 16, 2023
Processing time: 139 Days and 14.4 Hours
Core Tip

Core Tip: Gastroesophageal reflux disease (GERD) is a pathologic process requiring prompt assessment and treatment. The manifestations of GERD, especially in young children vary making it a challenge to diagnose. Combined esophageal pH-MII manometry has increased the diagnostic accuracy of GERD and helped explain its pathogenesis. Medication should be targeted to the underlying GERD pathogenesis, if known, and to minimize complications.