Retrospective Cohort Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Mar 16, 2022; 14(3): 129-141
Published online Mar 16, 2022. doi: 10.4253/wjge.v14.i3.129
Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions: A single-center study
Carlos Robles-Medranda, Juan I Olmos, Miguel Puga-Tejada, Roberto Oleas, Jorge Baquerizo-Burgos, Martha Arevalo-Mora, Raquel Del Valle Zavala, Joao Autran Nebel, Daniel Calle Loffredo, Hannah Pitanga-Lukashok
Carlos Robles-Medranda, Juan I Olmos, Miguel Puga-Tejada, Roberto Oleas, Jorge Baquerizo-Burgos, Martha Arevalo-Mora, Raquel Del Valle Zavala, Joao Autran Nebel, Daniel Calle Loffredo, Hannah Pitanga-Lukashok, Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas, Guayaquil 090505, Ecuador
Author contributions: Robles-Medranda C contributed to study conception, design, drafting; Olmos JI, Del Valle Zavala R, Nebel JA, Calle Loffredo D and Pitanga-Lukashok H contributed to study design, acquisition of data; Puga-Tejada M and Oleas R contributed to study design; Baquerizo-Burgos J, Puga-Tejada M and Oleas R contributed to study drafting, acquisition/analysis of data; Arevalo-Mora M did final database study consolidation and encryption, data acquisition; Robles-Medranda C, Olmos JI, Del Valle Zavala R, Nebel JA, Calle Loffredo D, Pitanga-Lukashok H, Puga-Tejada M, Oleas R and Arevalo-Mora M contributed to critical revision of important intellectual content; all authors did final approval of the version to be published.
Institutional review board statement: The study was approved by the Institutional Review Board of Instituto Ecuatoriano de Enfermedades Digestivas.
Informed consent statement: All study participants, and their legal guardians, provided informed written consent prior to study enrolment.
Conflict-of-interest statement: Robles-Medranda C reports other from Pentax Medical, other from Boston Scientific, other from Steris, other from Medtronic, other from Motus, other from Micro-tech, other from G-Tech Medical Supply, other from CREO Medical, other from Mdconsgroup, outside the submitted work; The other authors declare no conflicts of interest.
Data sharing statement: The data that support the findings of this study are openly available by contacting the corresponding author.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos Robles-Medranda, FASGE, MD, Chief Doctor, Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas, Av. Abel Romero Castillo y Av. Juan Tanca Marengo, Torre Vitalis, Mezanine 3, Guayaquil 090505, Ecuador. carlosoakm@yahoo.es
Received: July 27, 2021
Peer-review started: July 27, 2021
First decision: November 11, 2021
Revised: December 15, 2021
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: March 16, 2022
Processing time: 232 Days and 0.9 Hours
Core Tip

Core Tip: This retrospective study compared the accuracy of endoscopic ultrasound (EUS) and associated techniques such as EUS-guided fine needle aspiration (EUS-FNA), contrast-enhanced EUS (CE-EUS), EUS-guided fiberoptic probe cystoscopy (cystoscopy), EUS-guided direct intracystic micro-forceps biopsy (mFB), and EUS-guided needle-based confocal laser-endomicroscopy (nCLE) for the detection of potentially malignant pancreatic cystic lesions (PCLs) in 129 patients. Patients were allocated to three cohorts: those evaluated via EUS alone; via EUS-FNA, CE-EUS and/or cystoscopy; and with mFB plus nCLE. We observed that combining EUS, mFB, and nCLE had a statistically significant improved detection of potentially malignant PCLs compared to any of the evaluated techniques alone.