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World J Gastrointest Endosc. Feb 16, 2022; 14(2): 77-84
Published online Feb 16, 2022. doi: 10.4253/wjge.v14.i2.77
Exposed endoscopic full-thickness resection for duodenal submucosal tumors: Current status and future perspectives
Antonino Granata, Alberto Martino, Francesco Paolo Zito, Dario Ligresti, Michele Amata, Giovanni Lombardi, Mario Traina
Antonino Granata, Dario Ligresti, Michele Amata, Mario Traina, Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS–ISMETT, Palermo 90127, Italy
Alberto Martino, Francesco Paolo Zito, Giovanni Lombardi, Department of Gastroenterology and Digestive Endoscopy, AORN “Antonio Cardarelli”, Napoli 80131, Italy
Author contributions: Granata A, Martino A, Zito FP and Ligresti D designed the research and wrote, edited and finalized the text; Martino A, Ligresti D and Amata M performed literature search and analyzed the data; Lombardi G and Traina M reviewed the paper for important intellectual content.
Conflict-of-interest statement: No conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alberto Martino, MD, Staff Physician, Department of Gastroenterology and Digestive Endoscopy, AORN “Antonio Cardarelli”, Via Antonio Cardarelli 9, Napoli 80131, Italy. alberto-martino@libero.it
Received: March 20, 2021
Peer-review started: March 20, 2021
First decision: July 17, 2021
Revised: July 31, 2021
Accepted: January 13, 2022
Article in press: January 13, 2022
Published online: February 16, 2022
Processing time: 326 Days and 18.9 Hours
Core Tip

Core Tip: Exposed endoscopic full-thickness resection (EFTR) is a promising minimally invasive alternative to surgery for the removal of gastrointestinal submucosal tumors (SMTs) originating from the muscularis propria. To date, evidence concerning duodenal exposed EFTR is lacking, mainly due to both the technical difficulty and concerns about an effective closure of the transmural defect. However, given the non-negligible morbidity and mortality associated with duodenal surgery, the recent availability of dedicated endoscopic devices able to achieve a full-thickness defect closure could help in overcoming these concerns. Our study aimed to review the current evidence regarding exposed EFTR for deep duodenal SMTs.