Published online Oct 16, 2022. doi: 10.4253/wjge.v14.i10.642
Peer-review started: June 3, 2022
First decision: June 27, 2022
Revised: July 29, 2022
Accepted: September 13, 2022
Article in press: September 13, 2022
Published online: October 16, 2022
Core Tip: Cronkhite-Canada syndrome (CCS) is a rare acquired polyposis with unknown aetiology. To date about 500 cases have been reported worldwide. We herein report an Egyptian patient with CCS. Most of CCS cases were reported from Japan, and to our knowledge, our case is the first case reported from Egypt and North Africa. Cases presenting with gastrointestinal (GI) polyposis and marked thickened gastric mucosa and folds represent challenging cases and diagnostic dilemmas. The diagnosis was based on history, physical examination, endoscopic findings, and histology. CCS is typically characterized by GI symptoms, such as diarrhea and skin changes (e.g., alopecia, pigmentation, and nail dystrophy), while endoscopic features include diffuse polyps throughout the entire GIT, except for the esophagus. Pathological types of polyps in CCS mainly include inflammatory, hyperplastic, hamartomatous, and/or adenomatous polyps. CCS can be complicated by many diseases and has a malignant tendency with a high mortality rate. Till now, there has been no uniform standard treatment for CCS.