Rao B H, Nair P, Priya SK, Vallonthaiel AG, Sathyapalan DT, Koshy AK, Venu RP. Role of endoscopic ultrasound guided fine needle aspiration/biopsy in the evaluation of intra-abdominal lymphadenopathy due to tuberculosis. World J Gastrointest Endosc 2021; 13(12): 649-658 [PMID: 35070026 DOI: 10.4253/wjge.v13.i12.649]
Corresponding Author of This Article
Anoop K Koshy, MBBS, MD, Department of Gastroenterology, Amrita Institute of Medical Sciences, AIMS Ponekkara, Kochi 682041, Kerala, India. akkoshy5@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Dec 16, 2021; 13(12): 649-658 Published online Dec 16, 2021. doi: 10.4253/wjge.v13.i12.649
Role of endoscopic ultrasound guided fine needle aspiration/biopsy in the evaluation of intra-abdominal lymphadenopathy due to tuberculosis
Harshavardhan Rao B, Priya Nair, S Krishna Priya, Archana George Vallonthaiel, Dipu T Sathyapalan, Anoop K Koshy, Rama P Venu
Harshavardhan Rao B, Priya Nair, S Krishna Priya, Anoop K Koshy, Rama P Venu, Department of Gastroenterology, Amrita Institute of Medical Sciences, Kochi 682041, Kerala, India
Archana George Vallonthaiel, Department of Pathology, Amrita Institute of Medical Sciences, Kochi 682041, Kerala, India
Dipu T Sathyapalan, Department of Internal Medicine, Amrita Institute of Medical Sciences and Research Centre, Kochi 682041, Kerala, India
Author contributions: Priya SK helped in subject recruitment and data entry of the study; Rao B H and Nair P were involved with data analysis, interpretation and drafted the manuscript; George A and Sathyapalan DT gave initial insight related to the pathology and management of TB; Koshy AK and Venu RP revised the article critically for important intellectual content.
Institutional review board statement: This study was approved by the Amrita Institute of Medical Sciences Research Review Board (Kochi, Kerala, India).
Informed consent statement: All study participants or their legal guardian provided informed written consent for personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anoop K Koshy, MBBS, MD, Department of Gastroenterology, Amrita Institute of Medical Sciences, AIMS Ponekkara, Kochi 682041, Kerala, India. akkoshy5@gmail.com
Received: May 26, 2021 Peer-review started: May 26, 2021 First decision: June 17, 2021 Revised: June 22, 2021 Accepted: June 28, 2021 Article in press: June 28, 2021 Published online: December 16, 2021 Processing time: 201 Days and 17 Hours
Core Tip
Core Tip: Intra-abdominal lymphadenopathy due to tuberculosis (TB) poses a significant diagnostic challenge primarily due to difficulty in tissue acquisition. Endoscopic ultrasound guided fine needle aspiration/biopsy (EUS-FNA/B) has shown promise in the evaluation of TB presenting with mediastinal lymph nodes; however, its role in intra-abdominal lymphadenopathy due to TB remains unclear. In this study, a large cohort of patients who underwent EUS-FNA/B were studied. EUS-FNA/B was found to have a sensitivity and specificity of 86% and 93%, respectively, with a high diagnostic accuracy of 88% in the evaluation of intra-abdominal lymphadenitis due to TB. This study provides valuable data on the pivotal role of EUS-FNA/B in the evaluation of this difficult sub-group of patients. However, the validity of these findings in populations with low prevalence of TB needs further evaluation.
