Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Oct 16, 2021; 13(10): 491-501
Published online Oct 16, 2021. doi: 10.4253/wjge.v13.i10.491
Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study
Hideaki Miyamoto, Hideaki Naoe, Jun Morinaga, Kensuke Sakisaka, Sayoko Tayama, Kenshi Matsuno, Ryosuke Gushima, Masakuni Tateyama, Takashi Shono, Masanori Imuta, Satoru Miyamaru, Daizo Murakami, Yorihisa Orita, Yasuhito Tanaka
Hideaki Miyamoto, Hideaki Naoe, Kensuke Sakisaka, Sayoko Tayama, Kenshi Matsuno, Ryosuke Gushima, Masakuni Tateyama, Yasuhito Tanaka, Department of Gastroenterology and Hepatology, Kumamoto University Hospital, Kumamoto 860-8556, Japan
Jun Morinaga, Department of Clinical Investigation, Kumamoto University Hospital, Kumamoto 860-8556, Japan
Takashi Shono, Department of Gastroenterology, Kumamoto Chuo Hospital, Kumamoto 860-8556, Japan
Masanori Imuta, Department of Radiology, Kumamoto University Hospital, Kumamoto 860-8556, Japan
Satoru Miyamaru, Daizo Murakami, Yorihisa Orita, Department of Otolaryngology-Head and Neck Surgery, Kumamoto University Hospital, Kumamoto 860-8556, Japan
Author contributions: Miyamoto H, Naoe H, Morinaga J, Shono T and Tanaka Y were involved in the analysis and interpretation of data and drafting the manuscript; Sakisaka K, Tayama S, Matsuno K and Gushima R participated in the study coordination and acquisition of data; Tateyama M, Imuta I, Miyamaru S, Murakami D, and Orita Y critically revised the manuscript for important intellectual content; Tanaka Y approved the final version of the article for publication; All authors approved the final version.
Institutional review board statement: This study has been ethically approved by the Kumamoto University Ethics Committee (Approval No. 1851).
Conflict-of-interest statement: The authors declare no conflicts of interest associated with this manuscript.
Data sharing statement: All data relevant to the study are included in the article. No additional data available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yasuhito Tanaka, MD, Professor, Department of Gastroenterology and Hepatology, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. ytanaka@kumamoto-u.ac.jp
Received: March 6, 2021
Peer-review started: March 6, 2021
First decision: July 3, 2021
Revised: July 26, 2021
Accepted: September 16, 2021
Article in press: September 16, 2021
Published online: October 16, 2021
Core Tip

Core Tip: This is the first study to explore the detection modality of oropharyngeal and hypopharyngeal squamous cell carcinomas (SCC). In this study, 31.4% of pharyngeal SCCs (15.4% of oropharyngeal SCCs and 42.3% of hypopharyngeal SCCs) were detected by gastrointestinal endoscopy. The clinical characteristics of the lesions detected by gastrointestinal endoscopy include a higher proportion of asymptomatic cases, cTis-1 cases, cases with no lymph node metastasis and cases treated by endoscopic laryngo-pharyngeal surgery/endoscopic submucosal dissection, leading to a better prognosis. This study highlights the important role of gastrointestinal endoscopy in the early detection and treatment of SCC in the otolaryngology field.