Iosif E, Rees C, Beeslaar S, Shamali A, Lauro R, Kyriakides C. Gastrointestinal bleeding as initial presentation of extramedullary plasma cell neoplasms: A case report and review of the literature. World J Gastrointest Endosc 2019; 11(4): 308-321 [PMID: 31040892 DOI: 10.4253/wjge.v11.i4.308]
Corresponding Author of This Article
Evangelia Iosif, MD, MSc, Surgeon, Department of Gastrointestinal Surgery, Frimley Park Hospital, Frimley Health NHS Foundation Trust, Portsmouth Road, Frimley, Camberley GU16 7UJ, United Kingdom. e.iosif@nhs.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Evangelia Iosif, Awad Shamali, Roberto Lauro, Charis Kyriakides, Department of Gastrointestinal Surgery, Frimley Park Hospital, Frimley, Camberley GU16 7UJ, United Kingdom
Clare Rees, Department of Haematology, Frimley Park Hospital, Frimley, Camberley GU16 7UJ, United Kingdom
Salome Beeslaar, Department of Histopathology, Frimley Park Hospital, Frimley, Camberley GU16 7UJ, United Kingdom
Author contributions: Iosif E, Shamali A, Kyriakides C and Lauro R designed the study; Iosif E, Rees C, Beeslar S contributed to data acquisition and interpretation; Iosif E, Rees C and Kyriakides C wrote the manuscript. The final manuscript was approved by all authors. Rees C and Kyriakides C were the supervising consultants.
Informed consent statement: Informed consent obtained from the patient in the form of pre-operative written consent.
Conflict-of-interest statement: All authors declare no conflict of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Evangelia Iosif, MD, MSc, Surgeon, Department of Gastrointestinal Surgery, Frimley Park Hospital, Frimley Health NHS Foundation Trust, Portsmouth Road, Frimley, Camberley GU16 7UJ, United Kingdom. e.iosif@nhs.net
Telephone: +44-125-2649406
Received: February 17, 2019 Peer-review started: February 17, 2019 First decision: March 11, 2019 Revised: March 27, 2019 Accepted: April 8, 2019 Article in press: April 9, 2019 Published online: April 16, 2019 Processing time: 60 Days and 11.1 Hours
Core Tip
Core tip: The involvement of gastrointestinal tract by plasma cell neoplasms and the manifestation as gastrointestinal bleeding is very rare. However, patients can be profoundly unstable on presentation requiring immediate diagnosis and intervention. As the existing literature is very scattered and it mainly consists of case reports, we are aiming with our present work not only to describe our experience but also to review, consolidate and discuss information about diagnosis and management of this rare cause of gastrointestinal bleeding. The management these patients requires a multidisciplinary team approach and should involve not only the gastroenterology and surgical teams but also haematology and oncology teams for achievement of the best possible outcomes.
