Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Oct 16, 2019; 11(10): 515-522
Published online Oct 16, 2019. doi: 10.4253/wjge.v11.i10.515
Risk factors for the development of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with asymptomatic common bile duct stones
Hirokazu Saito, Tatsuyuki Kakuma, Ikuo Matsushita
Hirokazu Saito, Ikuo Matsushita, Department of Gastroenterology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Minami-ku, Kumamoto City, Kumamoto 862-0965, Japan
Tatsuyuki Kakuma, Department of Biostatics Center, Medical School, Kurume University, 67, Asahimachi, Kurume City, Fukuoka 830-0011, Japan
Author contributions: All authors equally contributed to the following criteria for authorship: Conception and design, analysis and interpretation of data, drafting of the article, critical revision of the article for important intellectual content, and final approval of the article.
Institutional review board statement: This study was reviewed and approved by the institutional review boards of both participating institutions: Kumamoto Chuo Hospital, Kumamoto City Hospital and Saiseikai Kumamoto Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patients agreed to treatment by written consent.
Conflict-of-interest statement: There are no conflicts of interest to declare in relation to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hirokazu Saito, MD, Chief Doctor, Department of Gastroenterology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Minami-ku, Kumamoto City, Kumamoto 862-0965, Japan. arnestwest@yahoo.co.jp
Telephone: +81-96-3703111 Fax: +81-96-3704017
Received: May 5, 2019
Peer-review started: May 8, 2019
First decision: August 2, 2019
Revised: August 21, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 16, 2019
Processing time: 165 Days and 8.9 Hours
Core Tip

Core tip: The objective of this study was to examine the risk factors for the development of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in patients with asymptomatic common bile duct (CBD) stones. In multivariate analysis, precut sphincterotomy, biliary balloon sphincter dilation, and trainee endoscopists were significant risk factors for PEP. ERCP for asymptomatic CBD stones should be performed by experienced endoscopists. When performing precut sphincterotomy or biliary balloon sphincter dilation in patients with asymptomatic CBD stones, prophylactic pancreatic stent placement is strongly recommended to prevent PEP.