Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Sep 16, 2022; 14(9): 555-563
Published online Sep 16, 2022. doi: 10.4253/wjge.v14.i9.555
Clinical profile, diagnostic yield, and procedural outcomes of single balloon enteroscopy: A tertiary care hospital experience
Maha Inam, Masood M Karim, Umar Tariq, Faisal Wasim Ismail
Maha Inam, Umar Tariq, Medical College, Aga Khan University Hospital, Karachi 74800, Pakistan
Masood M Karim, Faisal Wasim Ismail, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
Author contributions: Inam M participated in the acquisition, analysis, and interpretation of the data, and assisted in manuscript writing and review; Karim MM participated in the acquisition and interpretation of the data, and assisted in manuscript writing and review; Tariq U participated in the acquisition of the data and assisted in manuscript writing and review; Ismail FW conceptualized, designed, and supervised the study, participated in the acquisition and interpretation of the data, and assisted in manuscript writing and review; all authors have read and approved the final manuscript.
Institutional review board statement: Approval was obtained for this study from the Ethical Review Committee of the Aga Khan University Hospital, Karachi, Pakistan.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrolment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Faisal Wasim Ismail, FACG, FACP, FCPS, MBBS, Associate Professor, Department of Medicine, Aga Khan University Hospital, National Stadium Road, Karachi 74800, Pakistan. faisal.ismail@aku.edu
Received: April 16, 2022
Peer-review started: April 16, 2022
First decision: May 12, 2022
Revised: May 21, 2022
Accepted: August 10, 2022
Article in press: August 10, 2022
Published online: September 16, 2022
ARTICLE HIGHLIGHTS
Research background

Single balloon enteroscopy (SBE) is a procedure that has greatly improved the access to small bowel visualization, particularly of the mid and distal parts of the small bowel. In addition to being used as a diagnostic tool, SBE can also be used to perform a number of therapeutic interventions. SBE is a relatively safe procedure with a low incidence of complications and a good diagnostic and therapeutic yield. One of the most common indications generally seen is intestinal bleeding.

Research motivation

Since SBE is a relatively new procedure, there is still an absence of viable literature about it from the developing world countries like Pakistan. Due to the good yields from this procedure, proper adaptation of this technique in these places can greatly be used to improve healthcare outcomes particularly pertaining to small bowel problems by improving timely diagnosis and management.

Research objectives

To investigate the indications, procedures, findings, and safety of SBE procedures and to correlate their effects on the disease outcomes.

Research methods

We performed a retrospective descriptive study at a tertiary care hospital in Pakistan and investigated all the SBE procedures carried out between July 2013 and December 2021. A total of 56 patients underwent 61 SBE procedures during this time period. We collected data using patient files and electronic health records using a structured proforma. It was interpreted and then categorized and analyzed using the SPSS software.

Research results

Our study population consisted of 56 patients who underwent 61 SBE procedures at a tertiary care hospital over the study period. The mean age of the sample was 50.93 ± 16.16 years and 53.6% of the sample was male. The most common comorbidities in the patient population were hypertension (39.3%) and diabetes mellitus (25.0%). The most common indications for conducting the SBE procedure were obscure gastrointestinal bleed (39.3%), chronic diarrhea (19.7%), and unexplained anemia (16.4%). Other indications included enteric thickening or inflammatory changes on imaging, space occupying lesions, persistent vomiting, weight loss, and malabsorption syndromes. Most of the procedures were conducted in the endoscopy suite while 9.8% (n = 6) required the operation room due to patient comorbidities or being in conjunction with a surgical procedure. The majority of the procedures were carried under monitored anesthesia care (93.4%) while the rest were done under general anesthesia. Most procedures were diagnostic (91.8%) and completed without complications (95.1%). The depth of examination ranged from 95 cm to 500 cm with a mean of 282.05 ± 90.04 cm. The most common enteroscopy findings were inflammation and ulcerations (29.5%), followed by masses (19.7%) and vascular malformations (14.8%). Biopsy samples were taken in 33 of the cases and the most common biopsy finding was non-specific inflammation (63.6%). As a result of the findings, a new diagnosis was made in 47.5% of the cases and a previous one was ruled out in 24.6% of them; 65.6% of the cases had a change in management.

Research conclusions

Through our study findings, we concluded that SBE is a useful method in diagnosing small bowel problems with a good yield. It is also relatively safe and has a low risk of complications.

Research perspectives

More research needs to be conducted on the usage and yields from SBE procedures in low-middle income countries with larger samples. There also needs to be a standardized method to record the details of enteroscopy procedures.