Inoue F, Hirata D, Iwatate M, Hattori S, Fujita M, Sano W, Sugai T, Kawachi H, Ichikawa K, Sano Y. New application of endocytoscope for histopathological diagnosis of colorectal lesions. World J Gastrointest Endosc 2022; 14(8): 495-501 [PMID: 36158633 DOI: 10.4253/wjge.v14.i8.495]
Corresponding Author of This Article
Mineo Iwatate, Doctor, Gastrointestinal Center and Institute of Minimally-invasive Endoscopic Care (i-MEC), Sano Hospital, 2-5-1 Shimizugaoka, Tarumi-ku, Kobe 655-0031, Hyogo, Japan. m.iwatate15@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fumihiro Inoue, Daizen Hirata, Mineo Iwatate, Santa Hattori, Mikio Fujita, Wataru Sano, Yasushi Sano, Gastrointestinal Center and Institute of Minimally-invasive Endoscopic Care (i-MEC), Sano Hospital, Kobe 655-0031, Hyogo, Japan
Tamotsu Sugai, Molecular Diagnostic Pathology, Iwate Medical University School of Medicine, Shiwa-gun 028-3694, Iwate, Japan
Hiroshi Kawachi, Department of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto 135-8550, Tokyo, Japan
Kazuhito Ichikawa, Department of Pathology, Noda Hospital, Noda 270-0237, Chiba, Japan
Author contributions: Inoue F, Hirata D, Iwatate M, Hattori S, Fujita M, Sano W and Sano Y contributed to the study concept and design; Sugai T, Kawachi H and Ichikawa K contributed to read endocytopathological images; Inoue F, Hirata D, Iwatate M and Sano Y contributed to the data analysis and interpretation; Inoue F contributed to draft the manuscript; and Sugai T, Kawachi H, Ichikawa K and Sano Y contributed to the critical revision of the manuscript for intellectual content.
Institutional review board statement: The study protocol was reviewed and approved by the Institutional Review Board at Sano Hospital (No. 202106-02).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors have no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mineo Iwatate, Doctor, Gastrointestinal Center and Institute of Minimally-invasive Endoscopic Care (i-MEC), Sano Hospital, 2-5-1 Shimizugaoka, Tarumi-ku, Kobe 655-0031, Hyogo, Japan. m.iwatate15@gmail.com
Received: February 18, 2022 Peer-review started: February 18, 2022 First decision: April 12, 2022 Revised: April 23, 2022 Accepted: July 20, 2022 Article in press: July 20, 2022 Published online: August 16, 2022 Processing time: 178 Days and 0.5 Hours
ARTICLE HIGHLIGHTS
Research background
Based on the background of the shortage of histopathologists, we explore the new application of endocytoscope for directly observing histopathological specimens of colorectal lesions and storing them as endocyto-pathological images with their endoscopic images.
Research motivation
Endocyto-pathological images taken by endoscopists potentially reduce the burden of histopathologists and facilitate holding clinicopathological conferences more simply.
Research objectives
To assess the feasibility of endocyto-pathological images taken by an endoscopist as adequate materials for histopathological diagnosis.
Research methods
This was a single-center prospective pilot study. Three gastrointestinal pathologists were asked to diagnose 40 cases of endocyto-pathological images of colorectal specimens (Each case contained seven images: one loupe image, three low-magnification images, and three ultra-high magnification images). The participants chose hyperplastic polyp or low-grade adenoma for 20 cases of endocyto-pathological images (10 hyperplastic polyps, and 10 Low-grade adenomas in conventional histopathology) in study 1 and high-grade adenoma/shallow invasive cancer or deep invasive cancer for 20 cases [10 tumor in situ (Tis)/T1a and 10 T1b] in study 2.
Research results
Agreement between the endocyto-pathological and conventional histopathological diagnosis by the three gastrointestinal pathologists was 100% (95%CI: 94.0%–100%) in studies 1 and 2. The interobserver agreement among the three gastrointestinal pathologists was 100%, and the κ coefficient was 1.00 in both studies.
Research conclusions
Endocyto-pathological images were adequate and reliable materials for histopathological diagnosis.
Research perspectives
Endocyto-pathological images taken by endoscopists will reduce the growing burden on histopathologists, including their time and cost, when especially used with the computer-aided diagnosis system.
