Bar-Moshe Y, Mazeh H, Grozinsky-Glasberg S. Non-functioning pancreatic neuroendocrine tumors: Surgery or observation? World J Gastrointest Endosc 2017; 9(4): 153-161 [PMID: 28465781 DOI: 10.4253/wjge.v9.i4.153]
Corresponding Author of This Article
Dr. Haggi Mazeh, Department of Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, PO Box 24035, Jerusalem 91240, Israel. hmazeh@hadassah.org.il
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yehonatan Bar-Moshe, Haggi Mazeh, Department of Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem 91240, Israel
Simona Grozinsky-Glasberg, Neuroendocrine Tumor Unit, Hadassah-Hebrew University Medical Center, Jerusalem 91240, Israel
Author contributions: Bar-Moshe Y, Mazeh H and Grozinsky-Glasberg S collected, reviewed, and summarized the data.
Conflict-of-interest statement: The authors report no financial or ethical conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Haggi Mazeh, Department of Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, PO Box 24035, Jerusalem 91240, Israel. hmazeh@hadassah.org.il
Telephone: +972-2-5844550 Fax: +972-2-5844584
Received: August 28, 2016 Peer-review started: August 30, 2016 First decision: September 27, 2016 Revised: October 23, 2016 Accepted: January 11, 2017 Article in press: January 12, 2017 Published online: April 16, 2017 Processing time: 229 Days and 3.9 Hours
Abstract
Incidentally detected, sporadic, nonfunctional pancreatic neuroendocrine tumors are increasingly diagnosed on imaging studies performed for unrelated purposes. Although their resection is usually recommended, controversy still exists regarding their optimal management, due to their highly variable and difficult to predict biologic behavior. Recently, several studies and guidelines advocated an expectant management approach in small size, low grade, incidentally diagnosed nonfunctional pancreatic neuroendocrine tumors. The aim of this study is to review and summarize the available literature addressing nonfunctional pancreatic neuroendocrine tumors, with an emphasis on surgical management controversies.
Core tip: Nonfunctional pancreatic neuroendocrine tumors are increasingly diagnosed. Controversy exists regarding their optimal management. Expectant management in small size, low grade, incidentally diagnosed nonfunctional pancreatic neuroendocrine tumors has been suggested as an optional treatment. The aim of this study is to review the available literature addressing nonfunctional pancreatic neuroendocrine tumors, with an emphasis on surgical management controversies.
