Letters To The Editor
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 10, 2015; 7(16): 1230-1232
Published online Nov 10, 2015. doi: 10.4253/wjge.v7.i16.1230
PillCam COLON 2© as a pan-enteroscopic test in Crohn’s disease
Barry Hall, Grainne Holleran, Deirdre McNamara
Barry Hall, Grainne Holleran, Deirdre McNamara, Department of Gastroenterology, Adelaide and Meath Hospital, Dublin 24, Ireland
Author contributions: Hall B and McNamara D wrote this letter; all authors contributed equally to the gathering of data and statistical analysis.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Barry Hall, MD, Department of Gastroenterology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland. bhall@tcd.ie
Telephone: +353-01-8963843 Fax: +353-01-8962988
Received: July 28, 2015
Peer-review started: July 30, 2015
First decision: August 31, 2015
Revised: September 8, 2015
Accepted: September 29, 2015
Article in press: September 30, 2015
Published online: November 10, 2015
Processing time: 106 Days and 14.3 Hours
Abstract

A recent paper by Boal Carvalho et al demonstrates the potential of PillCam COLON 2© (PCC2) as a pan-enteric investigation in Crohn’s disease (CD). Our own prospective data in patients with known CD also shows good correlation between PCC2 and small/large bowel investigations (R = 0.896, P < 0.0004/R = 0.6667, P < 0.035). Larger studies are warranted to prospectively validate the use of PCC2 in the investigation and monitoring of both small and large bowel CD.

Keywords: Capsule endoscopy; Panenteroscopy; Small bowel Crohn’s disease; Mucosal healing; Colon capsule

Core tip: Mucosal healing has been shown to reduce the need for surgery and hospitalisation in patients with Crohn’s disease. Currently, assessing small bowel and colonic mucosal healing requires separate imaging/endoscopic modalities. Recent data suggests that the PillCam Colon 2© (PCC2) is capable of assessing mucosal healing of the small intestine and colon in a single, non-invasive test. Our own prospective data corroborates these findings demonstrating good correlation between investigations. Larger studies assessing the viability of PCC2 as a pan-enteric investigation are warranted.