Campos FG, Sulbaran M, Safatle-Ribeiro AV, Martinez CAR. Duodenal adenoma surveillance in patients with familial adenomatous polyposis. World J Gastrointest Endosc 2015; 7(10): 950-959 [PMID: 26265988 DOI: 10.4253/wjge.v7.i10.950]
Corresponding Author of This Article
Carlos Augusto Real Martinez, MD, PhD, Colorectal Division, State University of Campinas (UNICAMP, São Paulo), Postgraduate Program in Health Sciences at San Francisco University, Av. São Francisco de Assis, 218, Bragança Paulista, PC 12916-350, Brazil. caomartinez@uol.com.br
Research Domain of This Article
Surgery
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Aug 10, 2015; 7(10): 950-959 Published online Aug 10, 2015. doi: 10.4253/wjge.v7.i10.950
Duodenal adenoma surveillance in patients with familial adenomatous polyposis
Fábio Guilherme Campos, Marianny Sulbaran, Adriana Vaz Safatle-Ribeiro, Carlos Augusto Real Martinez
Fábio Guilherme Campos, Adriana Vaz Safatle-Ribeiro, Gastroenterology Department, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, PC 01411-000, Brazil
Marianny Sulbaran, Gastroenterology Department, University of São Paulo Medical School, São Paulo, PC 01411-000, Brazil
Carlos Augusto Real Martinez, Colorectal Division, State University of Campinas (UNICAMP, São Paulo), Postgraduate Program in Health Sciences at San Francisco University, Bragança Paulista, PC 12916-350, Brazil
Author contributions: Campos FG performed research and wrote the paper; Martinez CAR also performed research and wrote the paper; Sulbaran M and Safatle-Ribeiro AV contributed with photo documentation and endoscopic examinations.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Carlos Augusto Real Martinez, MD, PhD, Colorectal Division, State University of Campinas (UNICAMP, São Paulo), Postgraduate Program in Health Sciences at San Francisco University, Av. São Francisco de Assis, 218, Bragança Paulista, PC 12916-350, Brazil. caomartinez@uol.com.br
Telephone: +55-11-44389203 Fax: +55-11-44389203
Received: January 29, 2015 Peer-review started: January 29, 2015 First decision: April 13, 2015 Revised: May 7, 2015 Accepted: July 11, 2015 Article in press: July 14, 2015 Published online: August 10, 2015 Processing time: 200 Days and 15.9 Hours
Abstract
Familial adenomatous polyposis (FAP) is a hereditary disorder caused by Adenomatous Polyposis Gene mutations that lead to the development of colorectal polyps with great malignant risk throughout life. Moreover, numerous extracolonic manifestations incorporate different clinical features to produce varied individual phenotypes. Among them, the occurrence of duodenal adenomatous polyps is considered an almost inevitable event, and their incidence rates increase as a patient’s age advances. Although the majority of patients exhibit different grades of duodenal adenomatosis as they age, only a small proportion (1%-5%) of patients will ultimately develop duodenal carcinoma. Within this context, the aim of the present study was to review the data regarding the epidemiology, classification, genetic features, endoscopic features, carcinogenesis, surveillance and management of duodenal polyps in patients with FAP.
Core tip: The development of duodenal adenomas is considered a very common and important extracolonic manifestation in patients with familial adenomatous polyposis. Results from recently published studies have indicated the need for life-long surveillance of patients presenting with this condition due to a risk of malignization, especially in patients with severe adenomatosis. The present study discusses the incidence, endoscopic features and management of duodenal adenomas and reviews the published data regarding cancer prevention and surveillance.
