Brief Article
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World J Gastrointest Endosc. May 16, 2013; 5(5): 240-245
Published online May 16, 2013. doi: 10.4253/wjge.v5.i5.240
Risk of colorectal polyps in patients with sporadic gastric polyps: A case-control study
Daniel Gustavo Cimmino, José Manuel Mella, Pablo Luna, Raquel González, Lisandro Pereyra, Carolina Fischer, Adriana Mohaidle, Beatriz Vizcaino, Mario Andres Medrano, Adrián Hadad, Silvia Pedreira, Luis Boerr
Daniel Gustavo Cimmino, José Manuel Mella, Pablo Luna, Raquel González, Lisandro Pereyra, Carolina Fischer, Adriana Mohaidle, Beatriz Vizcaino, Mario Andres Medrano, Adrián Hadad, Silvia Pedreira, Luis Boerr, Digestive Endoscopy and Gastroenterology Units, Internal Medicine Department, Hospital Alemán, Buenos Aires, CP 1118, Argentina
Author contributions: Mella JM and Luna P made the conception and designed the study; Mella JM, González R, Pereyra L, Fischer C, Mohaidle A, Vizcaino B, Medrano MA and Hadad A acquisited the data; Cimmino DG, Mella JM and Luna P analysised and interpretated the data; Mella JM and Luna P drafted the article and revised it critically for important intellectual content; Cimmino DG, Mella JM, Luna P, Pedreira S and Boerr L made the final approval of the version.
Correspondence to: Dr. José Manuel Mella, MD, Digestive Endoscopy and Gastroenterology Units, Internal Medicine Department, Hospital Alemán, Avenida Pueyrredón 1640, Buenos Aires, CP 1118, Argentina. josemmella@hotmail.com
Telephone: +54-11-48277000 Fax: +54-11-48277211
Received: March 6, 2012
Revised: July 2, 2012
Accepted: March 15, 2013
Published online: May 16, 2013
Abstract

AIM: To assess the risk of colonic polyps, adenomas and advanced neoplastic lesions (ANL) in patients with sporadic gastric polyps, especially those with fundic gland polyps (FGP).

METHODS: Clinical records of patients who had performed an upper and a lower digestive endoscopy between September 2007 and August 2008 were retrospectively analyzed. A case-control study was carried out, calling patients with gastric polyps as “cases” and patients without gastric polyps as “controls”. The risk of colonic polyps, adenomas and ANL (villous component ≥ 25%, size ≥ 10 mm, or high grade dysplasia) was assessed [odds ratio (OR) and its corresponding 95%CI].

RESULTS: Two hundred and forty seven patients were analyzed: 78 with gastric polyps (cases) and 169 without gastric polyps (controls). Among the cases, the majority of gastric polyps were FGP (80%, CI: 69-88) and hyperplastic (20%, CI: 12-31); 25% had colonic polyps (25% hyperplastic and 68% adenomas, from which 45% were ANL). Among the controls, 20% had colonic polyps (31% hyperplastic and 63% adenomas, from which 41% were ANL). The patients with sporadic FGP had an OR of 1.56 (CI: 0.80-3.04) for colonic polyps, an OR of 1.78 (CI: 0.82-3.84) for colonic adenomas, and an OR of 0.80 (CI: 0.21-2.98) for ANL. Similar results were found in patients with gastric polyps in general.

CONCLUSION: The results of this study did not show more risk of colorectal adenomas or ANL neither in patients with sporadic gastric polyps nor in those with FGP.

Keywords: Colorectal polyps; Advanced neoplastic lesions; Gastric polyps; Fundic gland polyps gastric polyps; Case-control study

Core tip: The risk of colonic adenomas in patients who have sporadic gastric polyps, especially those of fundic gland polyps (FGP), is still to be definitely determined. The purpose of our study was to assess the risk of colonic polyps, adenomas and advanced neoplastic lesions in patients who have sporadic gastric polyps, especially of FGP, due to the fact that these are the most common gastric polyps in our population.