Brief Article
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastrointest Endosc. Jul 16, 2012; 4(7): 323-327
Published online Jul 16, 2012. doi: 10.4253/wjge.v4.i7.323
A study of the changes in the cause of peptic ulcer bleeding
Haruka Fujinami, Takahiko Kudo, Ayumu Hosokawsa, Kohei Ogawa, Takako Miyazaki, Jun Nishikawa, Shinya Kajiura, Takayuki Ando, Akira Ueda, Toshiro Sugiyama
Haruka Fujinami, Takahiko Kudo, Ayumu Hosokawsa, Takako Miyazaki, Jun Nishikawa, Shinya Kajiura, Takayuki Ando, Akira Ueda, Toshiro Sugiyama, Kouhei Ogawa, Department of Gastroenterology, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan
Author contributions: Fujinami H carried out the data analyses and drafted the manuscript; Kudo T, Hosokawsa A, Ogawa K, Miyazaki T, Nishikawa J, Kajiura S, Ando T and Ueda A carried out endoscopic examinations of the study subjects and data collection; Sugiyama T revised the manuscript and supervised the work.
Correspondence to: Haruka Fujinami, MD, Assistant Professor of Medicine, Department of Gastroenterology, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan. haruka52@med.u-toyama.ac.jp
Telephone: +81-76-4347301 Fax: +81-76-4345027
Received: August 19, 2011
Revised: February 2, 2012
Accepted: July 1, 2012
Published online: July 16, 2012
Abstract

AIM: To clarify the frequency of and changes in the cause of peptic ulcer bleeding.

METHODS: This study retrospectively evaluated the out- and inpatients who underwent endoscopy between 2002 to 2008. The subjects were patients presenting with peptic ulcer bleeding. The details of these patients were obtained from their endoscopic reports and medical records.

RESULTS: The rates of Helicobacter pylori (H. pylori) infection were significantly low (P = 0.039), while the proportion of nonsteroidal antiinflammatory drugs (NSAIDs) users and vascular disease significantly increased over the period studied (P = 0.034 and P = 0.04, respectively). However, there was no significant difference in the proportion of low-dose aspirin users (P = 0.832).

CONCLUSION: It’s found that the primary cause of peptic ulcer bleeding changed from H. pylori infection to use of NSAIDs over the 7-year period of study. It seems that the number of low-dose aspirin users has increased with the increase in the proportion of vascular disease. It is necessary to take measures to prevent peptic ulcer bleeding among NSAIDs and low dose aspirin users.

Keywords: Peptic ulcer bleeding; Gastroduodenal ulcer; Helicobacter pylori; Nonsteroidal antiinflammatory drugs; Low-dose aspirin