Takahashi H, Yamada E, Ohkubo H, Sakai E, Higurashi T, Uchiyama T, Hosono K, Endo H, Nakajima A. Relationship of human rectal aberrant crypt foci and formation of colorectal polyp: One-year following up after polypectomy. World J Gastrointest Endosc 2012; 4(12): 561-564 [PMID: 23293726 DOI: 10.4253/wjge.v4.i12.561]
Corresponding Author of This Article
Hirokazu Takahashi, MD, Gastroenterology Division, Yokohama City University Graduate School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan. hirokazu@med.yokohama-cu.ac.jp
Article-Type of This Article
Brief Article
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Hirokazu Takahashi, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Takuma Higurashi, Takashi Uchiyama, Kunihiro Hosono, Hiroki Endo, Atsushi Nakajima, Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
Author contributions: Takahashi H designed the study and wrote the manuscript; Yamada E, Ohkubo H, Sakai E, Higurashi T and Uchiyama T performed the colonoscopy; Hosono K and Endo H provided the collection of physical and imaging findings; Nakajima A providing appropriate advice for this work.
Supported by Grant-in-Aid for Research on the Third Term Comprehensive Control Research for Cancer from the Ministry of Health, Labour and Welfare, Japan to Nakajima A; a grant from the National Institute of Biomedical Innovation (NBIO) to Nakajima A; a grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan (KIBAN-B) to Nakajima A and (KIBAN-C) to Takahashi H
Correspondence to: Hirokazu Takahashi, MD, Gastroenterology Division, Yokohama City University Graduate School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan. hirokazu@med.yokohama-cu.ac.jp
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Received: October 13, 2011 Revised: October 20, 2012 Accepted: December 1, 2012 Published online: December 16, 2012
Abstract
AIM: To clarify the relationship of human rectal aberrant crypt foci and formation of colorectal polyp.
METHODS: Eighty-nine subjects were recruited from the population of Japanese individuals who underwent polypectomy at Yokohama City University Hospital. All patients had baseline adenomas removed at year 0 colonoscopy. Aberrant crypt foci (ACF) were defined as lesions in which the crypts were more darkly stained with methylene blue than normal crypts and had larger diameters, often with oval or slit-like lumens and a thicker epithelial lining.
RESULTS: A total of 366 ACFs were identified in 89 patients; all had baseline adenomas removed at the first examination (year 0) colonoscopy and returned for the second (year 1). ACF in the lower rectum were assessed at year 0 and study group were divided into two groups depend on ACF numbers, 0-3 or over 3. All participants were examined in the number and maximum size of adenoma. There was no statistical difference in number and maximum size of ACF at year 0, however, maximum size of adenoma was larger in over 3 group than 0-3 group at year 1.
CONCLUSION: The number of ACF may be a predictive factor of relatively large adenoma incidence in the pilot phase study.
