Liu XY, Sun XJ. Evaluation of Mayo endoscopic subscore in ulcerative colitis with concomitant primary sclerosing cholangitis. World J Gastrointest Endosc 2025; 17(2): 103448 [DOI: 10.4253/wjge.v17.i2.103448]
Corresponding Author of This Article
Xiu-Jing Sun, MD, Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Key Laboratory of Digestive Health, National Clinical Research Center for Digestive System Diseases, No. 95 Yong’an Road, Xicheng District, Beijing 100050, China. sunxiujing@ccmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Feb 16, 2025; 17(2): 103448 Published online Feb 16, 2025. doi: 10.4253/wjge.v17.i2.103448
Evaluation of Mayo endoscopic subscore in ulcerative colitis with concomitant primary sclerosing cholangitis
Xin-Yuan Liu, Xiu-Jing Sun
Xin-Yuan Liu, Xiu-Jing Sun, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Key Laboratory of Digestive Health, National Clinical Research Center for Digestive System Diseases, Beijing 100050, China
Author contributions: Liu XY contributed to this work and wrote this article; Sun XJ edited and revised this article; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Jing Sun, MD, Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Key Laboratory of Digestive Health, National Clinical Research Center for Digestive System Diseases, No. 95 Yong’an Road, Xicheng District, Beijing 100050, China. sunxiujing@ccmu.edu.cn
Received: November 25, 2024 Revised: January 14, 2025 Accepted: January 17, 2025 Published online: February 16, 2025 Processing time: 83 Days and 2 Hours
Abstract
This article relates to the discussion of a recent study published by Wohl et al. Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease that affects the intra- and extrahepatic bile ducts and is strongly associated with ulcerative colitis (UC). Endoscopic evaluation of UC is feasible and reliable in routine clinical practice, and the Mayo endoscopic subscore (MES) is one of the most commonly used endoscopic evaluation measures for UC. Patients with PSC-UC are at higher risk of developing cancer and biliary tract cancer. Endoscopic scoring alone appears unreliable, and histopathological evaluation is essential to accurately assess and make effective therapeutic decisions for PSC-UC. Therefore, we aimed to discuss the accuracy of MES in patients with UC and PSC-UC and to explore the consistency between MES and the Nancy histological index.
Core Tip: Patients with ulcerative colitis and primary sclerosing cholangitis have a high risk of colonic neoplasia and are more likely to have pancolitis, backwash ileitis, and rectal sparing. Both endoscopic and histological inflammation evaluation are important for the diagnosis and treatment of ulcerative colitis with concomitant primary sclerosing cholangitis. Therefore, this study aimed to explore the consistency between endoscopic and histological evaluation.
