Conti CB, Mulinacci G, Tamini N, Jaconi M, Zucchini N. Colonic ductal adenocarcinoma case report: New entity or rare ectopic degeneration? World J Gastrointest Endosc 2023; 15(3): 191-194 [PMID: 37034967 DOI: 10.4253/wjge.v15.i3.191]
Corresponding Author of This Article
Clara Benedetta Conti, Doctor, Interventional Endoscopy, ASST Monza, Ospedale San Gerardo, 33 Via G.B. Pergolesi, Monza 20900, Italy. benedetta.conti1@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Mar 16, 2023; 15(3): 191-194 Published online Mar 16, 2023. doi: 10.4253/wjge.v15.i3.191
Colonic ductal adenocarcinoma case report: New entity or rare ectopic degeneration?
Clara Benedetta Conti, Giacomo Mulinacci, Nicolò Tamini, Marta Jaconi, Nicola Zucchini
Clara Benedetta Conti, Giacomo Mulinacci, Interventional Endoscopy, ASST Monza, Ospedale San Gerardo, Monza 20900, Italy
Nicolò Tamini, Department of Surgery, ASST Monza, Ospedale San Gerardo, Monza 20900, Italy
Marta Jaconi, Nicola Zucchini, Department of Pathology, ASST Monza, Ospedale San Gerardo, Monza 20900, Italy
Author contributions: Conti CB and Zucchini N designed and directed the project; Conti CB and Mulinacci G wrote the first draft of the manuscript with support of Tamini N and Jaconi M; Zucchini N and Jaconi M performed the histological analysis; Zucchini N. supervised the study and reviewed for important intellectual contents. All authors approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Clara Benedetta Conti, Doctor, Interventional Endoscopy, ASST Monza, Ospedale San Gerardo, 33 Via G.B. Pergolesi, Monza 20900, Italy. benedetta.conti1@gmail.com
Received: December 22, 2022 Peer-review started: December 22, 2022 First decision: January 3, 2023 Revised: January 9, 2023 Accepted: February 8, 2023 Article in press: February 8, 2023 Published online: March 16, 2023 Processing time: 83 Days and 14 Hours
Abstract
BACKGROUND
Ectopic pancreatic tissue is a congenital anomaly where a part of pancreatic tissue is located outside of the pancreas and lacks vascular or anatomical communication with it but shows the same histological features. Currently, the literature reports only two anecdotal cases of malignant transformation of colonic ectopic pancreas.
CASE SUMMARY
We present a case of an 81-year-old patient presenting with anemia, with right colonic neoplasia and carbohydrate antigen 19-9 above the normal values. She underwent laparoscopic right hemicolectomy. The final histology was consistent with a primitive adenocarcinoma with ductal morphology and solid-predominant growth pattern. Benign ectopic pancreatic tissue was absent in the surgical specimen.
CONCLUSION
The case describes a very rare complete degeneration of a colonic ectopic pancreatic tissue. However, the absence of benign ectopic pancreatic tissue in the surgical specimen is suggestive of the first description of a primitive ductal adenocarcinoma of the colon.
Core Tip: Ectopic pancreatic tissue is a congenital anomaly. Currently, only two anecdotal cases of malignant transformation of colonic ectopic pancreatic tissue have been described. We present a case of an 81-year-old patient with a primitive adenocarcinoma of the right colon, with ductal morphology and solid-predominant growth pattern. Carbohydrate antigen 19-9 value was above the normal values, and both pancreas and biliary tree were healthy. Benign ectopic pancreatic tissue was missing in the surgical specimen. This observation is suggestive of a complete degeneration of a rare colonic ectopic pancreatic tissue or, even more interesting, the first description of a primitive ductal adenocarcinoma of the colon.
