Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Oct 16, 2022; 14(10): 636-641
Published online Oct 16, 2022. doi: 10.4253/wjge.v14.i10.636
Hemostasis of massive bleeding from esophageal tumor: A case report
Aleksei A Kashintsev, Dmitriy S Rusanov, Mariya V Antipova, Sergey V Anisimov, Oleg K Granstrem, Nikolai Yu Kokhanenko, Konstantin V Medvedev, Eldar B Kutumov, Anastasya A Nadeeva, Vitali Proutski
Aleksei A Kashintsev, Sergey V Anisimov, Oleg K Granstrem, Vitali Proutski, Pandx Ltd., Whittlesford, Cambridge, CB22 4NW, United Kingdom
Dmitriy S Rusanov, Mariya V Antipova, Nikolai Yu Kokhanenko, Konstantin V Medvedev, Eldar B Kutumov, Anastasya A Nadeeva, Pandx LLC., Saint-Petersburg 194100, Russia
Author contributions: Kashintsev AA, Anisimov SV, Granstrem OK, Kutumov EB, Nadeeva AA and Proutski V designed the study; Kashintsev AA, Rusanov DS, Antipova MV, Kokhanenko NY and Medvedev KV performed the study; Kashintsev AA, Anisimov SV, Granstrem OK, and Proutski V analyzed the results and wrote the manuscript; all authors have read and approve the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Aleksei A Kashintsev, MD, PhD, Director of Medicine and Technology, Surgeon, Pandx Ltd., Whittlesford, 1 Royston Road, Cambridge, CB22 4NW, United Kingdom.
Received: May 4, 2022
Peer-review started: May 4, 2022
First decision: June 16, 2022
Revised: June 24, 2022
Accepted: September 13, 2022
Article in press: September 13, 2022
Published online: October 16, 2022

Esophageal cancer is a common type of cancer and serious bleeding from esophageal tumors can occur in routine clinical practice. The arrest of bleeding from esophageal tumor is not a trivial task, which can sometimes require nonstandard solutions. We report a case of successful hemostasis of massive bleeding from esophageal tumor performed by a novel two-balloon catheter inserted endoscopically, with a local hemostatic treatment applied.


A 36-years old male patient with advanced esophageal cancer developed bleeding from the tumor following endoscopic stenting with a self-expanding metal stent. Due to the ineffectiveness of standard approaches, after a medical conference, the patient was treated with a novel method based on the use of a two-balloon catheter creating an isolated area in esophagus and locally dispersing hemostatic polysaccharide powder inside the isolated interior. Hemostasis was successful and subsequent endoscopic examination revealed the presence of organized clot and localized defect, which was coagulated in a planned manner.


The authors present a new catheter-based method of hemostasis of esophageal tumor bleeding.

Keywords: Esophageal cancer, Esophageal bleeding, Two-balloon catheter, Endoscopic hemostasis, Hemostatic polysaccharide powder, Case report

Core Tip: We describe a novel method of managing difficult-to-treat condition using an original device/ catheter that we developed. Our experience of managing gastrointestinal and, in particular, esophageal bleeding suggests that treatment of such conditions is a major challenge with no readily available and reliably working solutions. Success depends on multiple factors, all subject to limitation of time available for decision-making and application of treatment methods. A major advantage of our method is its ease of use and ability to be deployed by physicians of all levels and in all hospital settings. We believe that our method can help save many lives.