Smirnov AA, Kiriltseva MM, Lyubchenko ME, Nazarov VD, Botina AV, Burakov AN, Lapin SV. Peroral endoscopic myotomy in a pregnant woman diagnosed with mitochondrial disease: A case report. World J Gastrointest Endosc 2021; 13(5): 155-160 [PMID: 34046152 DOI: 10.4253/wjge.v13.i5.155]
Corresponding Author of This Article
Aleksandr N Burakov, Research Fellow, Department of Endoscopy, Pavlov First Saint Petersburg State Medical University, L’va Tolstogo Str. 6-8, Saint Petersburg 197022, Russia. aleksandr.medox@yandex.ru
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. May 16, 2021; 13(5): 155-160 Published online May 16, 2021. doi: 10.4253/wjge.v13.i5.155
Peroral endoscopic myotomy in a pregnant woman diagnosed with mitochondrial disease: A case report
Alexander A Smirnov, Maya M Kiriltseva, Mariya E Lyubchenko, Vladimir D Nazarov, Anna V Botina, Aleksandr N Burakov, Sergey V Lapin
Alexander A Smirnov, Maya M Kiriltseva, Mariya E Lyubchenko, Aleksandr N Burakov, Department of Endoscopy, Pavlov First Saint Petersburg State Medical University, Saint Petersburg 197022, Russia
Vladimir D Nazarov, Sergey V Lapin, Center for Molecular Medicine, Pavlov First Saint Petersburg State Medical University, Saint Petersburg 197022, Russia
Anna V Botina, Department of Pathology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg 197022, Russia
Author contributions: Smirnov AA and Lyubchenko ME performed peroral endoscopic myotomy, reviewed the literature and contributed to manuscript drafting; Kiriltseva MM performed the gastroenterology consultation; Burakov AN and Kiriltseva MM reviewed the literature and contributed to manuscript drafting; Nazarov VD and Lapin SV performed the genetic tests and interpretation and contributed to manuscript drafting; Botina AV provided the histology report; Burakov AN and Kiriltseva MM were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Aleksandr N Burakov, Research Fellow, Department of Endoscopy, Pavlov First Saint Petersburg State Medical University, L’va Tolstogo Str. 6-8, Saint Petersburg 197022, Russia. aleksandr.medox@yandex.ru
Received: December 19, 2020 Peer-review started: December 19, 2020 First decision: February 15, 2021 Revised: March 6, 2021 Accepted: April 26, 2021 Article in press: April 26, 2021 Published online: May 16, 2021 Processing time: 131 Days and 7.7 Hours
Abstract
BACKGROUND
Achalasia is a primary esophageal motility disease characterized by impairment of normal esophageal peristalsis and absence of relaxation of the lower esophageal sphincter. Sometimes is can be a part of some genetic disorders. One of the causes of gastrointestinal motility disorders, including achalasia, is mitochondrial defects.
CASE SUMMARY
We report about a pregnant woman with a history of symptoms associated with inherited mitochondrial disease, which was confirmed by genetic tests, and who was treated via peroral endoscopic myotomy.
CONCLUSION
Peroral endoscopic myotomy is possible treatment option for a pregnant woman with achalasia caused by mitochondrial disease.
Core Tip: Achalasia is a primary esophageal motility disease. Sometimes is can be a part of some genetic disorders. One of the causes of gastrointestinal motility disorders, including achalasia, is mitochondrial defects. We report about a pregnant woman with a history of symptoms associated with inherited mitochondrial disease, which was confirmed by genetic tests, and who was successfully treated via peroral endoscopic myotomy.
