Copyright
©The Author(s) 2017.
World J Hepatol. Feb 18, 2017; 9(5): 278-287
Published online Feb 18, 2017. doi: 10.4254/wjh.v9.i5.278
Published online Feb 18, 2017. doi: 10.4254/wjh.v9.i5.278
Table 1 Pooled data of vitamin D levels and liver fibrosis from the 12 included studies
Year | Author | Country | Design | n | HCV GT | HIV | Definition of vitamin D insufficiency (I)/deficiency (D) | Outcome (serum vitamin D and liver fibrosis) | P value/OR 95%CI | GRADE quality of evidence very low = 1, low = 2, moderate = 3, high = 4 and strength of recommendation: 2 = strong 1 = weak |
2010 | Petta | Italy | Prospective | 197 | 1 | No | < 30 ng/mL for low vitamin D level | Low 25(OH)D associated with severe fibrosis (F3/F4) | 0.942 [0.893, 0.994] P = 0.009 | GRADE 3 |
Strong | ||||||||||
2011 | Terrier | France | Prospective | 189 | 1,-4 other | Yes | < 10 ng/mL D, 10-30 ng/mL (I) | Low 25(OH)D correlate with severe fibrosis (F3/F4) | P = 0.04 | GRADE 3 |
Strong | ||||||||||
2012 | Lange | Sweden | Retrospective | 496 | 1, 4 | No | < 10 ng/mL D, < 20 ng/mL (I) | Advanced fibrosis stage F2-F4 vs F0-F1 associated with low 25(OH)D | 0.31 [0.12, 0.82] P = 0.018 | GRADE 2 |
Weak | ||||||||||
2012 | Weintraub | United States | Cross-sectional | 171 | 1 | No | < 20 ng/mL or < 30 ng/mL (I) | Higher 25(OH)D predictive of milder fibrosis (F0-F2) in white patients but not in African Americans | P = 0.007 | GRADE 2 |
Weak | ||||||||||
2012 | Baur | Switzerland | Cohort | 251 | 1, 3 | No | < 20 ng/mL (I) | (1) 25(OH)D lower in more advanced fibrosis (F2 vs F0-1); (2) low 25-OH vitamin D associated with rapid fibrosis progression rate. | P = 0.005, | GRADE 3 |
P = 0.013 | ||||||||||
Strong | ||||||||||
2013 | El-Maouche | United States | Prospective | 116 | - | Yes | < 15 ng/mL (D) | (1) The prevalence of significant fibrosis (F2 ≥ 2) was similar among those with and without low | P = 0.43 | GRADE 3 |
Vitamin D; (2) low 25(OH)D not associated with significant fibrosis after adjusting for other confounders | 1.37 [0.77, 2.44] | |||||||||
2013 | Mandorfer | Austria | Prospective | 65 | 1, 4 | Yes | < 10 ng/mL D, 10-30 ng/mL (I) | Patients with | P = 0.009 | Strong |
D-DEF displayed a higher prevalence of advanced liver | GRADE 3 | |||||||||
2013 | Kitson | Australia and New Zealand | Prospective | 274 | 1 | No | < 50 nmol/L D < 75 nmol/L (I) | Fibrosis than patients with D-NORM Baseline 25(OH)D level did not vary with fibrosis stage (F3/4 vs F0-2) | P = 0.18 | Strong |
GRADE 3 | ||||||||||
2013 | Amanzada | Germany | Prospective | 191 | 1 | Yes | < 30 ng/mL (I) | Low 25(OH)D associated with advance fibrosis (F0-2 vs F3/4) | P = 0.02 | Strong |
GRADE 3 | ||||||||||
2014 | Gerova | Bulgaria | Retrospective | 296 | 1, 4 | No | < 25 nmol/L (D), 25-50 nmol/L for profound (I), 50 –80 nmol/L for mild (I) | Lower 25OHD levels were registered in cases with advanced fibrosis compared to those with mild or absent fibrosis | P >0.05 | Strong |
GRADE 2 | ||||||||||
2014 | Guzman-Fulgencio | Spain | Retrospective | 174 | 1, 4 | Yes | < 10 ng/mL (D), 10-30 ng/mL (I) | Low 25(OH)D deficiency associated with advanced fibrosis (F3/4 vs F0-2) | P = 0.005 | Weak |
GRADE 2 | ||||||||||
2015 | Esmat | Egypt | Prospective | 101 | 4 | No | < 20 ng/mL (D), 20-30 (I) | No correlation found between vitamin D levels and stage of liver fibrosis | P = 0.26 | Weak |
GRADE 3 | ||||||||||
Table 2 Selection criteria for inclusion and exclusion
Inclusion criteria |
Age ≥ 18 yr |
Studies including mono-infected HCV or co-infected HCV/HIV |
Studies that evaluated liver fibrosis stage, only based on liver histology |
Studies that reported serum or plasma 25(OH)D levels |
Exclusion criteria |
Age < 18 yr |
Other etiologies of liver disease, other than hepatitis C |
Studies that used non-invasive methods in evaluating liver fibrosis |
Inadequate data |
- Citation: Dadabhai AS, Saberi B, Lobner K, Shinohara RT, Mullin GE. Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data. World J Hepatol 2017; 9(5): 278-287
- URL: https://www.wjgnet.com/1948-5182/full/v9/i5/278.htm
- DOI: https://dx.doi.org/10.4254/wjh.v9.i5.278