Copyright ©The Author(s) 2017.
World J Hepatol. Apr 28, 2017; 9(12): 567-585
Published online Apr 28, 2017. doi: 10.4254/wjh.v9.i12.567
Table 1 New potential treatments for alcoholic hepatitis
TreatmentClassMechanism of action
ProbioticsGut microbiota modificationReduction of bacterial endotoxins and translocation
IL-22 recombinant proteinImmune modulationHepatoprotective: Antioxidant, apoptotic, proliferative, and antimicrobial properties
G-CSFGrowth factorLiver regeneration
Obeticholic acidFarnesoid X receptorImprovement in cholestasis
EmricasanCaspase inhibitorApoptosis, inflammation, and fibrosis inhibitor
Anakinra (Pentoxifylline + Zinc)IL-1 receptorDecreases hepatic inflammation
SAMeGlutathione precursorDecreases oxidative stress
MetadoxineAntioxidantDecreases oxidative stress and steatosis
ELADExtracorporeal human hepatic cell-based liver treatmentToxin removal, reduction of inflammation, liver regeneration