Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 28, 2017; 9(12): 567-585
Published online Apr 28, 2017. doi: 10.4254/wjh.v9.i12.567
Emerging concepts in alcoholic hepatitis
Phoenix Fung, Nikolaos Pyrsopoulos
Phoenix Fung, Nikolaos Pyrsopoulos, Department of Medicine, Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, United States
Author contributions: Fung P reviewed the literature, performed the majority of writing, and prepared the figures and illustrations; Pyrsopoulos N designed, co-authored and revised the manuscript.
Conflict-of-interest statement: In regards to affiliations, Phoenix Fung and Nikolaos Pyrsopoulos perform research for Vital Therapies and Gilead Sciences. Nikolaos Pyrsopoulos is a member of the scientific advisory board for Vital Therapies and advisory board for Gilead.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Nikolaos Pyrsopoulos, MD, PhD, MBA, Associate Professor of Medicine, Chief of Gastroenterology and Hepatology, Department of Medicine, Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, United States.
Telephone: +1-973-9725252 Fax: +1-973-9723144
Received: December 5, 2016
Peer-review started: December 6, 2016
First decision: January 16, 2017
Revised: February 21, 2017
Accepted: March 12, 2017
Article in press: March 13, 2017
Published online: April 28, 2017
Core Tip

Core tip: Current research of alcoholic hepatitis pathophysiology via translational research has provided insight to novel therapeutic options. Recovery from severe alcoholic hepatitis with assistance of gut microbiota modification, immune modulators, stimulation of liver regeneration, caspase inhibitors, farnesoid X receptors, and extracorporeal liver assist device may be promising.