Copyright
©The Author(s) 2016.
World J Hepatol. Sep 8, 2016; 8(25): 1067-1074
Published online Sep 8, 2016. doi: 10.4254/wjh.v8.i25.1067
Published online Sep 8, 2016. doi: 10.4254/wjh.v8.i25.1067
Table 1 Demographical and clinical characteristics of the chronic hepatitis C patients classified by cluster of differentiation 36 genotype
CD36 genotype | ||||
Variable | AA | AG | GG | P-value |
No. of patients, n (%) | 22 (30.1) | 40 (54.8) | 11 (15.1) | --- |
Age (yr) | 48.1 ± 11.7 | 51.4 ± 11.1 | 53.7 ± 15.3 | 0.38 |
Gender (F/M) | (12/10) | (21/19) | (7/4) | 0.68 |
BMI (kg/m2) | 26.6 ± 4.1 | 24.9 ± 4.2 | 24.4 ± 3.1 | 0.52 |
Duration of infection (yr) | 26.9 ± 10.1 | 25.2 ± 8.1 | 25.4 ± 7.4 | 0.62 |
HCV genotype 1, n (%) | 15 (68.2) | 27 (67.5) | 8 (72.7) | 0.40 |
HCV genotype 2, n (%) | 5 (22.7) | 9 (22.5) | 3 (27.3) | |
HCV genotype 3, n (%) | 2 (9.1) | 4 (10) | 0 (0) |
Table 2 Daily dietary intake of the chronic hepatitis C patients classified by cluster of differentiation 36 genotype
CD36 genotype | |||||
Variable | Reference values | AA | AG | GG | P-value |
Total calories | - | 2531.3 ± 301.3 | 1902.5 ± 396.1 | 1873.5 ± 345.7 | 0.021a |
CH (%) | 50-60 | 55.4 ± 10.5 | 54.3 ± 8.9 | 53.2 ± 6.4 | 0.76 |
Protein (%) | 15 | 17.2 ± 4.6 | 16.3 ± 3.9 | 16.4 ± 2.9 | 0.81 |
Fat (%) | < 30 | 34.9 ± 7.5 | 27.5 ± 7.2 | 24.9 ± 1.1 | 0.001299a |
SFA (%) | < 7 | 16.1 ± 6.1 | 8.1 ± 3.2 | 8.4 ± 2.7 | 0.2 × 10-6a |
MUFA (%) | 20 | 13.1 ± 3.4 | 12.8 ± 7.6 | 12.1 ± 5.4 | 0.94 |
PUFA (%) | 10 | 8.8 ± 6.5 | 5.6 ± 4.2 | 5.2 ± 1.3 | 0.11 |
Table 3 Daily intake of food group servings in chronic hepatitis C patients classified by cluster of differentiation 36 genotype
CD36 genotype | |||||
Variable | Reference values | AA | AG | GG | P-value |
Sugars | 0-3 | 5.7 ± 4.3 | 5.5 ± 4.8 | 5.2 ± 4.1 | 0.85 |
Meat | 2-3 | 5.7 ± 1.6 | 5.1 ± 2.8 | 4.4 ± 2.2 | 0.15 |
Fruits | 2-4 | 2.0 ± 1.8 | 1.7 ± 0.9 | 1.4 ± 1.1 | 0.43 |
Vegetables | 3-5 | 2.1 ± 1.6 | 1.9 ± 1.1 | 1.6 ± 0.8 | 0.42 |
Fats | 0-3 | 6.5 ± 1.7 | 4.3 ± 3.1 | 3.9 ± 2.2 | 0.0032071 |
Milk | 1-3 | 1.0 ± 0.7 | 0.8 ± 0.7 | 0.8 ± 0.9 | 0.86 |
Legumes | 1-2 | 1.0 ± 0.7 | 0.9 ± 0.7 | 0.8 ± 0.7 | 0.88 |
Cereals | 6-11 | 10.3 ± 5.4 | 9.6 ± 5.8 | 9.0 ± 5.1 | 0.77 |
Table 4 Biochemical profile of the chronic hepatitis C patients classified by cluster of differentiation 36 genotype
CD36 genotype | ||||
Variable | AA | AG | GG | P-value |
Glucose (mg/dL) | 109.5 ± 59.3 | 106.7 ± 42.9 | 97.4 ± 19.8 | 0.78 |
TC (mg/dL) | 146.8 ± 35.1 | 162.2 ± 44.2 | 157.8 ± 51.1 | 0.40 |
TG (mg/dL) | 112.8 ± 43.3 | 140.8 ± 60.8 | 142.3 ± 51.1 | 0.30 |
HDL-c (mg/dL) | 42.7 ± 15.1 | 40.4 ± 13.1 | 33.8 ± 9.8 | 0.21 |
LDL-c (mg/dL) | 83.1 ± 28.8 | 95.4 ± 42.6 | 101.1 ± 42.6 | 0.44 |
VLDL-c (mg/dL) | 22.6 ± 8.7 | 28.2 ± 12.1 | 28.9 ± 10.1 | 0.27 |
ALT (IU/L) | 93.8 ± 42.6 | 73.4 ± 73.1 | 71.5 ± 46.4 | 0.38 |
AST (IU/L) | 91.7 ± 41.3 | 61.5 ± 40.3 | 69.8 ± 53.9 | 0.0281 |
GGT (IU/L) | 85.9 ± 56.2 | 66.4 ± 40.8 | 43.1 ± 33.2 | 0.18 |
Table 5 Kilopascals and aspartate aminotransferase to platelet ratio index score values by the severity of liver fibrosis among chronic hepatitis C patients
Variable | Mild fibrosis | Advanced fibrosis | P-value |
No. of patients, n (%) | 35 (47.9) | 38 (52.1) | - |
kPa | 6.5 ± 1.7 | 22.7 ± 13.4 | < 0.001 |
APRI score | 0.81 ± 0.33 | 1.78 ± 0.53 | < 0.001 |
Table 6 Association of the cluster of differentiation 36 genotype with the severity of liver fibrosis among chronic hepatitis C patients
CD36 genotype | Mild fibrosis n (%) | Advanced fibrosis n (%) | Genotype comparison | Odds ratio (95%CI) | P-value |
AA | 6 (17.1) | 16 (42.1) | AA vs GG | 3.20 (0.70-14.52) | 0.12 |
AG | 23 (65.7) | 17 (44.7) | AA vs AG | 3.60 (1.16-11.15) | 0.02 |
GG | 6 (17.1) | 5 (13.2) | AA vs AG/GG | 3.51 (1.18-10.45) | 0.02 |
- Citation: Ramos-Lopez O, Roman S, Martinez-Lopez E, Fierro NA, Gonzalez-Aldaco K, Jose-Abrego A, Panduro A. CD36 genetic variation, fat intake and liver fibrosis in chronic hepatitis C virus infection. World J Hepatol 2016; 8(25): 1067-1074
- URL: https://www.wjgnet.com/1948-5182/full/v8/i25/1067.htm
- DOI: https://dx.doi.org/10.4254/wjh.v8.i25.1067