Copyright ©The Author(s) 2016.
World J Hepatol. Jan 8, 2016; 8(1): 58-68
Published online Jan 8, 2016. doi: 10.4254/wjh.v8.i1.58
Table 1 Isolated biological criteria for the selection of candidates with hepatocellular carcinoma for liver transplantation
Ref.Pretrasplant AFP levels (ng/mL)Importance
Figueras et al[19]> 300Factor for mortality
Yao et al[16]> 1.000Reduced survival
Bruix[20]> 200Significant worse outcomes
Xu et al[21]> 400Higher tumor recurrence
Mailey et al[22]Low ( ≤ 20)Mediun and high: Higher mortality
Mediun (20-399)
High (≥ 400)
Muscari et al[23]DFSRecurrence
> 50046%62%
Chiao et al[24]> 1.000Reason for exclusion from the WL
Hameed et al[25]
Menon et al[26]> 10.000Reason for exclusion from the WL
Table 2 Selection criteria base on radiological/morphological tumor characteristics
Bismuth et al[30]Up to 3 nodulesBest results
Each < 3 cm
Mazzaferro et al[31]Single lesion < 5 cmDFS > 75%
< 3 lesions, each < 3 cmRecurrence < 15%
No macrovascular invasion
No extrahepatic disease
Löhe et al[34]Single tumor with size > 5 cmReduction in DFS
Yao et al[16]Single lesion ≤ 6 cmDFS > 75%
2-3 lesions each ≤ 4.5 cmRecurrence < 15%
Total tumor diameter ≤ 8 cm
Mazzaferro[41]Ordinates: n of tumorsProgressive reduction of 5 yr survival
Abscissas: Tumor size
Mazzaferro et al[42]Up to 7, as the sum of:71.2% 5 yr survival
Largest tumor in centimeter and n of tumors
Jang et al[46]10 as the sum of:If >: Decreased DFS
Largest tumor in cm and
n of tumors
Table 3 Selection criteria based on functional/radiological features of the tumor
Hiraoka et al[56]Hyperintensity on gadoxetic acid-enhanced MRIHCC with more malignant potential
Ferda et al[12]Hipervascularity or hiperaccumulation of (18)FDG/PET/with Dual-phase CT angiography (arterial/portal phase)Distinguishing between welland
Poorly differentiated HCC
Ochi et al[57]High positivity in (18)FDG/PET/CTIncrease the risk of early recurrence
Kornberg et al[58]mSUVReflects the existence of distant microsatellite
Kornberg[59]Positivity in (18)FDG/PET/CTStatistically significant lower survival post LT
Table 4 Combined morphological/biological selection criteria
DuBay et al[60]Liver tumor biopsyExcluding poorly differentiated tumors
Toso et al[52]TTV > 115 cm3Reduced survival at 3 yr (< 50%)
AFP > 400 ng/mLLimit for indication for LT
Lai et al[62]AFP > 400 ng/mLStrongest predictor for recurrence
Total tumor diameter > 8 cm
Duvoux et al[63]Model combining log10 AFP, tumor size and n of tumors: Score > or < 2Score greater that 2 predict a market increase in 5 yr risk of recurrence and decreased survival
Berry et al[66]AFP < 15 or > 15 ng/mLAFP levels predicts post-transplant survival independently of MC
Table 5 Japanese combined morphological/biological selection criteria for living-donor liver transplant
Importance: Limits for LDLT
Yang et al[67]T size (cm) ≤ 33.1-55.1-6.5> 6.5Patients with 3-6 points are transplantable
of tumors12-34-5> 5 or 6Those with 7-12 points are not transplantable
AFP (ng/mL)< 2020-200200.1-1.000< 1.000
Akamatsu et al[68]Up to 5 nodulesUpper limit for LDLT
Maximum diameter ≤ 5
Kaido et al[69]Less that 10 nodules, all < 5 cmUpper limit for LDLT
DCP < 400 mAu/mL
Shirabe et al[70]n of nodules: No limitUpper limit for LDLT
Maximun diameter: < 5 cm
DCP < 300 mAu/mL