Copyright ©The Author(s) 2015.
World J Hepatol. Feb 27, 2015; 7(2): 261-269
Published online Feb 27, 2015. doi: 10.4254/wjh.v7.i2.261
Table 1 Staging systems for hepatocellular carcinoma
ClassificationYearBackground Variables
Tumor statusLiver functionHealth status
Okuda staging1985850 Japanese patients50% liver involvementAscites, bilirubin, albumin-
BCLC staging1999Selected papersSize, number, vascular invasion, Okuda stageChild-Pugh, bilirubin, porta hypertensionPerformance status
CLIP score2000435 Italian patients50% liver involvement, vascular invasion, AFPChild-Pugh-
CUPI2002926 Chinese patientsTNM, AFPBilirubin, albumin, alkaline phosphatasePresence of symptoms
JIS score20033334 Japanese patientsTNM (Japanese)Child-Pugh-
m-JIS score200642269 Japanese patientsTNM (Japanese)Liver damage-
Tokyo score2005403 Japanese patientsSize, numberBilirubin, albumin-
Table 2 Treatment options for hepatocellular carcinoma in barcelona clinic liver cancer system and Japanese guidelines
Tumor numberTumor size (cm)Child-Pugh classTreatment
BCLC systemJapanese guidelines
Single2A, BResection1 Resection
2 Ablation
2.1-3A, B1 Resection1 Resection
2 Transplantation or ablation2 Ablation
3.1-5A, B1 ResectionResection
2 Transplantation
2 or 3 nodules ≤ 3A, BTransplantation or ablationResection or ablation
CPalliative careTransplantation
> 3A, BChemoembolization1 Resection
2 Chemoembolization
4 or more nodulesA, BChemoembolization1 Chemoembolization
2 Chemotherapy
CPalliative carePalliative care