Case Report
Copyright ©2014 Baishideng Publishing Group Inc.
World J Hepatol. Jul 27, 2014; 6(7): 532-537
Published online Jul 27, 2014. doi: 10.4254/wjh.v6.i7.532
Table 1 Hypercoagulable etiologies
Thrombophilic disordersLocal factors
Inherited disordersAcquired disordersInflammatoryRelated to surgery
Factor V Leyden mutationMyeloproliferative disordersCirrhosisPost liver transplant
Prothrombin mutationMalignancySepsisSplenectomy
Antithrombin IIIAntiphospholipid syndromePancreatitis/cholecystitisColectomy
Protein C deficiencyAnticardiolipin antibodyDiverticulitisUmbilical vein catheterization
Protein S deficiencyParoxysmal nocturnal hemoglobinuriaAppendicitisPortocaval shunting
Hyperhomocystein-emiaPeptic ulcer disease
Oral contraception pillsInflammatory bowel disease
Pregnancy/post-partumBlunt abdominal trauma
Table 2 Proposed mechanism for reduction in concentrations of procoagulant and anticoagulant proteins in patients with portal vein thrombosis
Hereditary or acquired thrombophilia
Reduced hepatic blood flow
Reduced synthesis
Portal hypertension
Portosystemic shunting
Clearance or consumption
Portal pyaemia or other local inflammatory disease
Portal vein thrombosis
Reduced levels of procoagulant and anticoagulant proteins