Transitions of histopathologic criteria for diagnosis of nonalcoholic fatty liver disease during the last three decades

Table 1 Histological criteria for diagnosis of nonalcoholic steatohepatitis used in the previous studies (1980-preset)

Ref.	Year	Steatosis	Inflammatory cell infiltration	Hepatocellular necrosis	Hepatocellular ballooning	Mallory-Denk body	Pericellular fibrosis
Ludwig et al[1]	1980	≥ Moderate	+	+
Falchuk et al[23]	1980	≥ Moderate				+	+
Diehl et al[26]	1988	≥ Mild		+		+1	+1
Nagore et al[25]	1988	≥ Mild	+		+	+	+
Lee et al[35]	1989	≥ Mild	+				+
Powell et al[28]	1990	≥ Moderate	+
Wanless et al[29]	1990	≥ 5%			+
Bacon et al[36]	1994	≥ Minimal	+
Laurin et al[37]	1996	≥ Minimal	+
George et al[38]	1998	≥ Minimal	+
Younossi et al[32]	1998	> 1/3	+	+
Matteoni et al[33]	1999	> 1/3	+	+	+2
Brunt et al[41]	1999	> 0%	+
Dixon et al[44]	2001	≥ Mild	+	+	+1		+1
Neuschwander-Tetri et al[2]	2003	≥ 5%	+		+
Bedossa et al[51]	2012	> 5%	+		+3

¹Either one;

²Modified in 2009[34];

³Normal-sized hepatocyte with clear reticular cytoplasm. +: Required; Blank: Not required.