Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia

Table 1 Baseline values

Group	Weight (g)	MAP (mmHg)	ICP (mmHg)
PCA + ammonia infusion + Cs	295.5 ± 11.8	110 ± 4.2	1.0 ± 0.2
PCA + ammonia infusion + vehicle	326.2 ± 15.3	103 ± 4.0	0.8 ± 0.2
PCA + saline infusion + Cs	320.8 ± 12.4	116 ± 2.0	0.6 ± 0.2
PCA + saline infusion + vehicle	308.3 ± 14.7	106 ± 4.2	0.8 ± 0.3

PCA: Portacaval anastomosis; Cs: Ciclosporin; MAP: Mean arterial pressure; ICP: Increased intracranial pressure.

Table 2 Baseline biochemistry

Group	Arterial pH	Arterial pCO2 (mmHg)	Arterial pO2 (mmHg)	Haemog-l obin (mmol/L)	Blood glucose (mmol/L)
PCA + ammonia infusion + Cs	7.46 ± 0.008	37.9 ± 1.2	136.6 ± 7.7	9.0 ± 0.19	6.4 ± 0.29
PCA + ammonia infusion + vehicle	7.47 ± 0.013	38.2 ± 0.4	130.2 ± 3.8	9.4 ± 0.26	5.9 ± 0.52
PCA + saline infusion + Cs	7.49 ± 0.005	35.7 ± 0.5	144.6 ± 1.7	8.6 ± 0.19	6.3 ± 0.21
PCA + saline infusion + vehicle	7.46 ± 0.002	37.9 ± 1.1	129.7 ± 6.7	9.2 ± 0.40	5.3 ± 0.12

PCA: Portacaval anastomosis; Cs: Ciclosporin.

Table 3 Biochemistry at t = 4 h

Group	ALT (U/L)	Arterial ammonia (μmol/L)	PP (arb. units)
PCA + ammonia infusion + Cs	525 ± 185	1165.5 ± 87.2	0.32 ± 0.01
PCA + ammonia infusion + vehicle	600 ± 266	900.5 ± 70	0.37 ± 0.02
PCA + saline infusion + Cs	470 ± 221	108.3 ± 5.9	0.40 ± 0.03
PCA + saline infusion + vehicle	830 ± 468	140.3 ± 15	0.33 ± 0.03

PCA: Portacaval anastomosis; Cs: Ciclosporin; ALT: Alanine transferase; PP: Coagulation factor II + VII + X.