Published online Sep 27, 2013. doi: 10.4254/wjh.v5.i9.513
Revised: June 8, 2013
Accepted: August 20, 2013
Published online: September 27, 2013
Core tip: Acute liver failure and hyperammonaemia can lead to severe brain oedema. Preserving mitochondrial function by treatment with ciclosporin has shown potential in in vitro studies. In this study we evaluated the effect of ciclosporin in a rat model of acute hyperammonaemia on intracranial pressure, brain water content and expression of the water channel aquaporin-4. We did not find a beneficial effect of ciclosporin on intracranial pressure, brain water content or aquaporin-4 expression.