Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients

Table 1 Study population baseline characteristics (491 patients)

Patients baseline characteristics
Female gender, n (%)	360/491 (73.3)
Median age, yr (IQR)	35 (30-41)
BMI (kg/m2), n (%) < 18.5 18.5-25 > 25	115 (23.4) 281 (57.2) 95 (19.4)
WHO clinical stage, n (%) 1 or 2 3 or 4	294/491 (60) 197/491 (40)
HIV serology, n (%) HIV-1 HIV-1 and HIV-2	476 (97) 15 (3)
Median CD4+ T-cell count (/mm3) (IQR)	341 (221-470)
CD4+ T-cell < 200/mm3, n (%)	112/491 (22.8)
Median plasma HIV RNA (Log10 copies/mL) (IQR)	4.87 (4.15-5.45)
Plasma HIV-1 RNA > 5 log10 copies/mL, n (%)	221/491 (45)
Serum transaminase level, n (%) AST > UNV	81/491 (16.5)
ALT > UNV	41/491 (8.4)

IQR: Interquartile range; BMI: Body mass index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; UNV: Upper normal value (50 UI/mL); WHO: World Health Organization; HIV: Human immunodeficiency viruses.

Table 2 Hepatitis B virus DNA quantitative values by hepatitis B virus infection type

Type of viral Binfection	Viral infection B DNA (UI/mL)
	Median	Interquartilerange	Range
HBeAg positive hepatitis	2.1 × 107	1.1 × 107-1.1 × 108	27200-1.1 × 108
HBeAg negative hepatitis	139 000	8760-1.1 × 108	3030-1.1 × 108
Viral B inactive chronic carriers	331	62-641	8-1540
Occult B infection	46	16-149	7-258

Table 3 Relationship between HBs antigen positivity and baseline characteristics

Baseline characteristics	Univariate analysis			Multivariate analysis
	HBsAg (+)1n = 66 (%)	HBsAg (-)1n = 425 (%)	P value	OR (95% CI)n = 491	P value
Age > 35 yr2	57.6	48	0.15	-	-
Gender, male	43.9	24	0.001	2.2 (1.3-3.8)	0.005
BMI < 18.5 kg/m2	34.9	21.7	0.06	-	-
WHO stage 43	13.6	3.8	0.003	3.2 (1.3-7.9)	0.01
AST > UNV	30.3	14.4	0.001	1.9 (1.02-3.6)	0.04
ALT > UNV	16.7	7.1	0.009	-	-
CD4+ T-cell < 200/mm3	34.9	20.9	0.01	-	-
HIV RNA ≥ 5 Log	59.1	42.8	0.02	1.5 (0.9-2.7)	0.12

¹HBsAg positive and HBsAg negative.

²median age.

³Stage four of World Health Organization (WHO) clinical classification or AIDS. BMI: Body mass index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; UNV: Upper normal value (50 UI/mL); HBsAg: HBs antigen.