Ductopenia related liver sarcoidosis

Table 1 Clinical course and laboratory Findings after treatment with ursodeoxycholic acid in our patient

Treatment with UDCA	ALP UI/L (N+ 30 - 100)	GGT UI/L (N + 5 - 45)	ALT UI/L (N + 6 - 45)	AST UI/L (N + 6 - 40)	Jaundicea
1996-07-15	520	1210	150	48	+++
1996-09-24	370	966	89	26	+++
1996-12-23	226	249	29	21	++
1997-02-21	123	215	31	22	0
1997-04-22	113	210	27	43	0
1997-07-08	134	235	26	17	0
1999-04-16	143	258	47	34	0
2000-05-05	103	152	40	29	0
2001-01-10	113	167	35	31	0
2002-12-05	88	170	30	36	0
2003-06-19	92	181	23	29	0

^aDegree of change: 0: Absent; ++: Moderate; +++: Marked; N: Value of laboratory; Abbreviations: ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; UDCA: Ursodeoxycholic acid.

Table 2 Epidemiological, clinical features and outcome of reported cases with hepatic sarcoidosis and ductopenia

Ref.	Age (Year)/Sex/Race	Jaundice	Maximum ALP	Maximun AST	Clinical outcome
[4]	29/M/Black	Yes	10 X	1 X	Died 9 years after diagnosis
	31/M/Black	Yes	14 X	5 X	Died 11 years after diagnosis
	23/M/Black	Yes	30 X	13 X	Alive, portal hypertension
	20/M/Black	Yes	35 X	9 X	Died 10 years after first seen
	33/M/Black	Yes	30 X	6 X	Died 18 years after first seen
[20]	56/M/White	Yes	3 X	4 X	Alive, no symptoms
[21]	50/F/Black	Yes	6 X	2 X	Alive, portal hypertension
	46/M/Black	Yes	3 X	2 X	Alive, portal hypertension
[15]	-/M/	Yes	9 X	4 X	Alive, no symptoms
[22]	62/F/-	No	10 X	2 X	Alive, cirrhosis
[23]	38/F/White	Yes	12 X	3 X	Died 26 years after diagnosis
	40/M/-	Yes	10 X	4 X	Died 10 years after diagnosis
[5]	27/M/Black	Yes	10 X	3 X	Alive, portal hypertension
	28/M/Black	No	9 X	2 X	alive, disabled
	44/M/Black	No	7 X	2 X	Alive, well
	24/F/Black	Yes	7 X	1 X	Alive, well
[24]	52/M/Black	No	8 X	1 X	Died, 4 years after diagnosis
[25]	44/M/-	No	4 X	1, 5 X	Alive, cirrhosis
[26]	62/M/-	No	1, 8 X	ND	Died, 3 years after diagnosis
Present case	54/F/White	Yes	5 X	1 X	Alive, cirrhosis

X: Upper limit of normal; ND: Not done; Ref: Reference; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase.