Farouj NE, Cadranel JFD, Mofredj A, Jouannaud V, Lahmiri M, Lann PL, Cazier A. Ductopenia related liver sarcoidosis. World J Hepatol 2011; 3(6): 170-174 [PMID: 22509431 DOI: 10.4254/wjh.v3.i6.170]
Corresponding Author of This Article
Jean François Cadranel, MD, Professor, CMHP, Liver, Gastroenteroly and Nutrition Department, Centre Hospitalier Laënnec BP 72 60100 Creil, France. jfrançois.cadranel@ch-creil.fr
Article-Type of This Article
Case Report
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World J Hepatol. Jun 27, 2011; 3(6): 170-174 Published online Jun 27, 2011. doi: 10.4254/wjh.v3.i6.170
Ductopenia related liver sarcoidosis
Nourr-Eddine Farouj, Jean-François D Cadranel, Ali Mofredj, Vincent Jouannaud, Maria Lahmiri, Pierre Le Lann, Alain Cazier
Nourr-Eddine Farouj, Ali Mofredj, Intensive Care Department, Centre Hospitalier Laënnec BP 72 60100 Creil, France
Jean-François D Cadranel, Vincent Jouannaud, Maria Lahmiri, Liver, Gastroenteroly and Nutrition Department, Centre Hospitalier Laënnec BP 72 60100 Creil, France
Pierre Le Lann, Chest and Lung Department, Centre Hospitalier Laënnec BP 72 60100 Creil, France
Alain Cazier, Pathological, Centre Hospitalier Laënnec BP 72 60100 Creil, France
Author contributions: Farouj NE wrote the manuscript; Cadranel JF was the patient’s main physician, made the diagnosis and wrote the manuscript. Mofredj A participated in manuscript writing; Lahmiri M and Jouannaud V and Le Lann P collected data; Cazier A made all pathological examinations and wrote pathological comments; all authors approved the submitted manuscript.
Correspondence to: Jean François Cadranel, MD, Professor, CMHP, Liver, Gastroenteroly and Nutrition Department, Centre Hospitalier Laënnec BP 72 60100 Creil, France. jfrançois.cadranel@ch-creil.fr
Received: January 8, 2011 Revised: May 16, 2011 Accepted: May 23, 2011 Published online: June 27, 2011
Abstract
Sarcoidosis is a systemic granulomatous disease which may involve many organs. In approximately 95% of patients there is liver involvement, with noncaseating hepatic granulomas occurring in 21 to 99% of patients with sarcoidosis. Liver involvement is usually asymptomatic and limited to mild to moderate abnormalities in liver biochemistry. The occurrence of jaundice in sarcoidosis is rare; extensive imaging procedures and the examination of liver biopsies permit a precise diagnostic. Ductopenia associated with sarcoidosis has been reported in less than 20 cases and can lead to biliary cirrhosis and liver- related death. We report here on a case of ductopenia-related sarcoidosis in which primary biliary cirrhosis and extrahepatic cholestasis have been carefully excluded. The patient follow up was 8 years. Although ursodesoxycholic acid appears to improve liver biochemistry it does not preclude the rapid occurrence of extensive fibrosis. A review of the literature of reported cases of ductopenia related to sarcoidosis is provided.
