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World J Hepatol. Jun 27, 2011; 3(6): 157-163
Published online Jun 27, 2011. doi: 10.4254/wjh.v3.i6.157
Published online Jun 27, 2011. doi: 10.4254/wjh.v3.i6.157
Table 1 Patient demographics and biochemical data
Variable | n = 117 |
Age in years | 50.4 (10.5) |
Male gender - no. (%) | 74 (63%) |
Etiology of liver disease - no. (%) | |
Viral | 46 (39%) |
Alcohol | 20 (17%) |
Cholestasis | 25 (21%) |
Other | 26 (22%) |
BMI (kg/m2) | 24.8 (5.0) |
Current smoking - no. (%) | 43 (37%) |
History of fracture - no. (%) | 10 (9%) |
MELD score | 15.2 (6.0) |
Calciuma (N 2.1 - 2.6 ng/L) | 2.41 (0.22) |
PTH - mean (SD)(N 1.1 - 6.8 ng/L) | 2.86 (2.44) |
25 OHD (N 40 - 200 μg/mL) | 32.2 (19.5) |
Total testosterone (N 10 - 29.5 nmol/L) | 12.0 (9.9) |
IGF-1 (μg /mL) (N, age and sex dependent) | 41.3 (54.0) |
TNFα (N < 8.1 ng /mL) | 14.8 (8.7) |
IL-6 (N < 9.7 ng /mL) | 17.1 (46.2) |
UNTx (N < 81 nmol BCE/ mmol creatinine) | 57.3 (36.4) |
Table 2 Clinical and Biochemical Data by Etiology of Cirrhosis
Variable | Viral | Alcohol | Cholestasis | Other |
n = 46 | n = 20 | n = 25 | n = 26 | |
BMI (kg/m2) | 25.4 (5.1) | 24.4 (5.3) | 23.3 (3.2) | 25.8 (5.9) |
MELD score | 15.1 (6.14) | 16.2 (6.14) | 14.2 (5.06) | 15.6 (6.51) |
Corrected calcium (nmol/L) | 2.39 (0.28) | 2.44 (0.21) | 2.37 (0.11) | 2.41 (0.22) |
PTH (ng/L) | 2.14 (1.2)a | 3.73 (2.7) | 2.83 (1.5) | 3.48 (3.9) |
25OHD (μg/L) | 30.6 (16.1) | 34.4 (20.1) | 37.0 (20.2) | 28.7 (17.0) |
Testosterone (nmol/L) | 12.7 (11.2) | 7.0 (4.5)b | 15.7 (7.4) | 12.2 (11.5) |
IGF-1 (μg/L) | 34.5 (47.3) | 28.3 (27.1) | 45.9 (47.7) | 59.5 (79.2) |
TNFα (ng/L) | 16.1 (10.9) | 13.7 (6.7) | 15.0 (8.4) | 13.0 (5.0) |
IL-6 (ng/L) | 26.7 (72.4) | 19.3 (20.7) | 7.1 (5.3) | 9.9 (12.2) |
UNTx (nmol BCE/mmol creatinine) | 54.9 (38.0) | 69.3 (25.2) | 56.5 (41.6) | 53.7 (36.2) |
Table 3 T-scores and prevalence of abnormal BMD between disease groups
Viral n = 46 | Alcohol n = 20 | Cholestasis n = 25 | Other n = 26 | P value | |
T-score lumbar spine mean (SD) | -1.08 (1.35) | -1.51 (1.35) | -1.43 (1.23) | -1.30 (1.43) | 0.552 |
T-score femoral neck mean (SD) | -1.11 (1.07) | -1.31 (1.02) | -1.30 (0.81) | -1.03 (1.05) | 0.706 |
Low BMD at 1 or both sites number (%) | 31 (67.4%) | 13 (65.0%) | 18 (72.0%) | 18 (69.2%) | 0.963 |
Low BMD lumbar spine number (%) | 22 (47.8%) | 11 (55.0%) | 15 (60.0%) | 18 (69.2%) | 0.556 |
Low BMD femoral neck number (%) | 26 (56.5%) | 12 (60.0%) | 15 (60.0%) | 14 (53.8%) | 0.993 |
Table 4 Correlation between BMD, bone turnover and variables of interest
Variable | T-score(lumbar spine) | T-score(femoral neck) | Urine NTx | |||
r Value | P Value | r Value | P Value | r Value | P Value | |
BMI | 0.324a | < 0.001 | 0.360a | < 0.001 | -0.249a | 0.013 |
MELD | -0.255a | 0.016 | -0.038 | 0.692 | 0.311a | 0.002 |
25OHD | 0.278a | 0.016 | 0.227a | 0.003 | -0.426a | < 0.001 |
Testosterone (males only) | 0.13 | 0.273 | 0.003 | 0.978 | -0.377a | 0.003 |
IGF-1 | 0.215a | 0.024 | 0.209a | 0.029 | -0.07 | 0.5 |
TNFα | -0.139 | 0.15 | -0.084 | 0.39 | 0.07 | 0.51 |
IL-6 | -0.137 | 0.19 | -0.073 | 0.49 | 0.276a | 0.015 |
Urine NTx | -0.346a | < 0.001 | -0.102 | 0.319 |
Table 5 Clinical and biochemical parameters ranked by severity of bone loss
Normal | Osteopenia | Osteoporosis | P value | |
BMI | 26.8 (5.1) | 24.4 (5.1)a | 22.9 (3.6)a | 0.006 |
MELD | 15.5 (5.9) | 14.2 (5.7) | 16.9 (6.5) | 0.18 |
25OHD | 33.9 (15.7) | 33.4 (20.2) | 27.9 (15.3) | 0.25 |
Testosterone | 11.1 (9.8) | 13.7 (10.8) | 10.1 (8.3) | 0.41 |
IGF-1 | 38.3 (35.5) | 44.4 (67.5) | 39.2 (46.1) | 0.86 |
TNFα | 14.3 (10.7) | 15.2 (7.6) | 14.7 (8.0) | 0.89 |
IL-6 | 11.8 (12.9) | 12.4 (14.0) | 15.6 (17.4) | 0.64 |
UNTx | 47.2 (27.3) | 59.4 (38.7) | 70.2 (41.6)b | 0.08 |
- Citation: Mitchell R, McDermid J, Ma MM, Chik CL. MELD score, insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease. World J Hepatol 2011; 3(6): 157-163
- URL: https://www.wjgnet.com/1948-5182/full/v3/i6/157.htm
- DOI: https://dx.doi.org/10.4254/wjh.v3.i6.157