Yinchenhao decoction alleviates obstructive jaundice liver injury by modulating epidermal growth factor receptor and constitutive androstane receptor signaling

Table 1 Qualitative results of Yinchenhao decoction granules

No.	tR (minute)	Formula	Adduct	m/z	Name
1	0.73	C7H6Cl2	(M-H)-	159.8779	2,6-Dichlorotoluene
2	0.78	C9H20N2O2	(M+H)+	189.1601	N6,N6,N6-Trimethyl-L-lysine
3	0.80	C6H14N4O2	(M+H)+	175.1191	L-Arginine
4	0.83	C4H9NO2	(M+H)+	104.1076	D(-)-2-Aminobutyric acid
5	0.85	C4H9NO3	(M+H)+	120.0657	L-(-)-Threonine
6	0.85	C4H9NO2	(M+H)+	104.1076	N,N-Dimethylglycine
7	0.85	C4H8N2O3	(M+H)+	133.0608	L-(-)-Asparagine
8	0.87	C6H14O6	(M-H)-	181.0712	Dulcitol
9	0.87	C6H12O7	(M-H)-	195.0503	Gluconic acid
10	0.90	C12H22O11	(M-H)-	341.1092	α,α-Trehalose
11	0.90	C6H10O8	(M-H)-	209.0297	D-Saccharic acid
12	0.92	C5H9NO2	(M+H)+	116.0709	D-(+)-Proline
13	0.93	C7H12O6	(M-H)-	191.0553	D-(-)-Quinic acid
14	1.35	C9H11NO3	(M+H)+	182.0815	L-tyrosine
15	1.53	C10H13N5O4	(M+H)+	268.1043	Adenosine
16	1.78	C6H10O5	(M-H)-	161.0447	Diethylpyrocarbonate
17	2.81	C16H22O10	(M+H)+	375.1287	Geniposidic acid
18	2.88	C9H17NO5	(M+H)+	220.1183	vitamin b5
19	3.19	C23H20O9	(M-H)-	439.1012	Pongamoside A
20	3.41	C7H6O4	(M-H)-	155.0341	3,4-Dihydroxybenzoic acid
21	3.41	C16H24O10	(M-H)-	375.1297	Mussaenosidic acid
22	3.52	C16H27NO11	(M-H)-	408.1516	LINUSTATIN
23	3.55	C16H18O9	(M-H)-	353.0878	Neochlorogenic acid
24	3.75	C11H9NO2	(M+H)+	188.0709	3-Indoleacrylic acid
25	4.38	C9H6O3	(M+H)+	162.9982	7-Hydroxycoumarine
26	4.38	C16H18O9	(M+H)+	355.1026	Chlorogenic acid
27	4.97	C17H24O10	(M+H)+	389.1229	Geniposide
28	4.97	C9H8O2	(M+H)+	149.0600	Phyllodulcin
29	4.97	C8H8O	(M+H)+	121.0650	Acetophenone
30	4.97	C10H10O4	(M+H)+	195.0652	Acetovanillin
31	4.97	C11H14O5	(M+H)+	227.1039	Genipin
32	4.97	C8H7N	(M+H)+	118.0656	Indole
33	4.97	C9H10O3	(M+H)+	167.0706	3',4'-Dihydroxyphenylacetone
34	5.41	C18H24N4O5	(M-H)-	375.1659	N-Acetylglycyl-N-[(2S)-5-amino-1,5-dioxo-2-pentanyl]-L-phenylalaninamide
35	6.17	C10H16O3	(M-H)-	183.1017	Ieodomycin D
36	6.20	C27H30O16	(M-H)-	609.1463	Rutin
37	6.52	C21H20O12	(M+H)+	465.1032	Quercetin-3β-D-glucoside
38	6.66	C11H12O5	(M-H)-	223.0609	Sinapinic acid
39	7.28	C9H8O3	(M+H)+	165.0546	4-Coumaric acid
40	7.28	C21H24O11	(M+H)+	453.1671	Aspalathin
41	7.33	C44H64O24	(M-H)-	975.3730	Crocin
42	7.40	C25H24O12	(M-H)-	515.1195	Isochlorogenic acid A
43	7.40	C25H24O12	(M-H)-	515.1195	4,5-Dicaffeoylquinic acid
44	8.18	C28H34O14	(M+H)+	595.3627	Fumotonaringin
45	7.46	C33H42O18	(M+H)+	727.2448	Naringenin 7-O-(2",6"-di-O-alpha-rhamnopyranosyl)-beta-glucopyranoside
46	8.14	C27H28O13	(M+H)+	561.1606	Cassiaoccidentalin A

Table 2 Qualitative results of blood ingredient in Yinchenhao decoction granules

No.	tR (minute)	Formula	Adduct	m/z	Name
1	0.87	C6H14O6	(M-H)-	181.0712	Dulcitol
2	2.81	C16H22O10	(M+H)+	375.1287	Geniposidic acid
3	3.19	C23H20O9	(M-H)-	439.1012	Pongamoside A
4	3.41	C16H24O10	(M-H)-	375.1297	Mussaenosidic acid
5	3.52	C16H27NO11	(M-H)-	408.1516	Linustatin
6	3.55	C16H18O9	(M-H)-	353.0878	Neochlorogenic acid
7	4.38	C16H18O9	(M+H)+	355.1026	Chlorogenic acid
8	4.97	C9H8O2	(M+H)+	149.0600	Phyllodulcin
9	4.97	C8H8O	(M+H)+	121.0650	Acetophenone
10	6.17	C10H16O3	(M-H)-	183.1017	Ieodomycin D
11	6.20	C27H30O16	(M-H)-	609.1463	Rutin