Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2025; 17(3): 101724
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.101724
Yinchenhao decoction alleviates obstructive jaundice liver injury by modulating epidermal growth factor receptor and constitutive androstane receptor signaling
Jun-Jian Liu, Han-Wei Mei, Yan-Yan Jing, Zhong-Lian Li, Su-Guo Wu, Hong-Xia Yuan, Xi-Bo Zhang
Jun-Jian Liu, Zhong-Lian Li, Xi-Bo Zhang, Department of Hepatobiliary and Pancreatic Surgery 2, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300102, China
Jun-Jian Liu, Tianjin Key Laboratory, Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300102, China
Han-Wei Mei, Department of Gastrointestinal Surgery 3, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 301617, China
Yan-Yan Jing, Su-Guo Wu, Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Hong-Xia Yuan, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Co-first authors: Jun-Jian Liu and Han-Wei Mei.
Co-corresponding authors: Hong-Xia Yuan and Xi-Bo Zhang.
Author contributions: Zhang XB and Liu JJ conceptualized and designed the research study; Liu JJ and Mei HW conducted the experiments and collected experimental data; Jing YY and Wu SG performed data analysis and interpretation; Liu JJ and Mei HW drafted the manuscript; Yuan HX and Li ZL critically revised and edited the manuscript for intellectual content; All authors reviewed and approved the final version of the manuscript. Liu JJ and Mei HW contributed equally to this work as co-first authors, with Liu JJ leading the experimental execution and data acquisition, and Mei HW assisting in experimental procedures and manuscript preparation. Zhang XB and Yuan HX served as co-corresponding authors, overseeing the project’s conceptual framework, experimental validation, and manuscript refinement. Zhang XB secured funding and supervised the overall research direction, while Yuan HX provided critical insights into data interpretation and coordinated revisions. Li ZL contributed to technical guidance and manuscript proofreading. This collaborative effort ensured the successful completion and publication of the study.
Supported by Tianjin Municipal Education Commission Scientific Research Program, China, No. 2022KJ271.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (license No. SYXK Jin 2020-0008). The experimental protocol was approved by the Animal Research Committee of Tianjin Medical University Nankai Hospital (approval No. NKYY-DWLL-2023-073).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xi-Bo Zhang, PhD, Full Professor, Department of Hepatobiliary and Pancreatic Surgery 2, Tianjin Nankai Hospital, Tianjin Medical University, No. 6 Changjiang Street, Nankai District, Tianjin 300102, China. nkzxb@163.com
Received: September 24, 2024
Revised: January 18, 2025
Accepted: March 4, 2025
Published online: March 27, 2025
Processing time: 182 Days and 13.3 Hours
Core Tip

Core Tip: Yinchenhao decoction (YCHD) alleviates obstructive jaundice-induced liver damage by enhancing bile acid metabolism and excretion. This study reveals that YCHD modulates the epidermal growth factor receptor signaling pathway, upregulates the constitutive androstane receptor, and promotes its nuclear localization, contributing to improved liver and kidney function. These findings provide insights into the molecular mechanisms behind YCHD's therapeutic effects on obstructive jaundice.