Gadoxetic acid-enhanced magnetic resonance imaging in the assessment of hepatic sinusoidal obstruction syndrome in a mouse model

Table 1 Histological features in sinusoidal obstruction syndrome

No.	Central vein endothelial damage	Central vein subendothelial hemorrhage	Sinusoidal hemorrhage	Lobular inflammation	Hepatocyte necrosis	Centrilobular fibrosis	All scores
1	2	1	2	1	0	0	6
2	0	1	1	0	0	0	2
3	1	1	1	1	0	0	4
4	1	1	1	0	0	0	3
5	0	1	1	0	0	2	2
6	1	0	0	1	0	0	2
7	1	0	0	0	0	0	1
8	1	1	0	1	1	1	5
9	1	1	1	1	0	1	5
10	2	2	1	1	1	1	8
11	1	2	1	1	0	1	6
12	1	2	2	1	1	1	8
13	2	3	3	3	0	0	11

Each pathological feature was assessed using a 4-point grading system: 0 = absent; 1 = mild; 2 = moderate; 3 = severe. All score = total scores of the six pathological features.

Table 2 Correlations between magnetic resonance imaging, albumin bilirubin, and total histological score

	T1pre	T1post	△T1%	ESP	ALBI
r	0.37	-0.70	0.68	0.79	-0.76
P value	0.095	< 0.001	< 0.001	< 0.001	< 0.001

T_1pre: T1 relaxation time before enhancement; T1post: T1 relaxation time 20 minutes after enhancement; △T1%: Reduction rate of T1 relaxation time; ESP: The first enhancement slope percentage in liver parenchyma; ALBI: Albumin and bilirubin.

Table 3 Magnetic resonance imaging and albumin/bilirubin in control and experimental groups

Parameters	Control group (n = 10)	Experimental group (n = 13)	P value
T1pre (millisecond)	659.13 ± 24.07	681.57 ± 40.58	0.137
T1post (millisecond)	408.87 ± 27.21	120.48 ± 53.71	< 0.001
△T1%	37.84 ± 5.46	82.40 ± 7.62	< 0.001
ESP	4.14 ± 0.95	19.67 ± 12.12	< 0.001
ALBI	0.95 ± 0.04	0.12 ± 0.89	< 0.001

T_1pre: T1 relaxation time before enhancement; T_1post: T1 relaxation time 20 minutes after enhancement; △T₁%: Reduction rate of T1 relaxation time; ESP: The first enhancement slope percentage in liver parenchyma; ALBI: Albumin and bilirubin.

Table 4 Correlation between magnetic resonance imaging, albumin/bilirubin and organic transporter polypeptide 1

	r	P value
T1pre	-0.06	0.803
T1post	-0.83	< 0.001
△T1%	0.82	< 0.001
ESP	0.85	< 0.001
ALBI	-0.56	0.005

T_1pre: T1 relaxation time before enhancement; T_1post: T1 relaxation time 20 min after enhancement; △T₁%: Reduction rate of T1 relaxation time; ESP: The first enhancement slope percentage in liver parenchyma; ALBI: Albumin and bilirubin; OATP1: Organic transporter polypeptide 1.