Retrospective Study
Copyright ©The Author(s) 2024.
World J Hepatol. Jul 27, 2024; 16(7): 1018-1028
Published online Jul 27, 2024. doi: 10.4254/wjh.v16.i7.1018
Table 1 Patient characteristics, n (%)
Characteristics
Total, 284 patients
Pos group, 200 patients
Neg group, 84 patients
P value
Age, year53.26 ± 11.4052.59 ± 11.1755.35 ± 11.880.054
Male259 (91.2)180 (90.0)79 (94.0)0.272
BMI, kg/m²22.64 ± 2.9322.51 ± 2.9622.95 ± 2.870.289
Diabetes22 (7.7)16 (8.0)6 (7.1)0.805
Hypertension48 (16.8)33 (16.5)15 (17.9)0.781
PLT, ×109/L185.00 (32.00-454.00)197.00 (40.00-427.00)155.50 (32.00-454.00)< 0.001b
PT, s12.05 (9.60-16.10)12.00 (9.60-14.90)12.15 (10.20-16.10)0.808
INR1.03 (0.82-1.40)1.03 (0.82-1.29)1.04 (0.88-1.40)0.861
ALB, g/L37.80 (25.10-65.50)37.40 (27.2-47.9)39.45 (25.10-65.50)0.026a
TBIL, mol/L13.60 (5.10-83.30)13.40 (5.10-83.30)13.95 (5.10-42.70)0.559
ALT, U/L33.00 (7.00-468.00)35.00 (7.00-468.00)26.00 (8.00-155.00)< 0.001b
AST, U/L37.00 (12.90-438.00)39.50 (18.00-438.00)30.50 (12.90-209.00)< 0.001b
GGT, U/L59.00 (12.00-951.00)66.00 (12.00-951.00)47.00 (13.00-705.00)0.008b
CHE, U/L6180.00 (1141.00-20174.00)6030.00 (1141.00-20174.00)6682.00 (2024.00-10368.00)0.496
CREA, μmol/L80.00 (3.00-371.00)78.00 (3.00-280.00)85.00 (46.00-371.00)< 0.001b
AFP, μg/L45.26 (0.00-1.14 × 106)53.92 (0.00-1.14 × 106)22.91 (0.00-927002.45)0.008b
1HBV-DNA, IU/mL3360.00 (0.00-3.53 × 107)46300.00 (101.00-3.53 × 107)0.00 (0.00-88.80)< 0.001b
CP score of 5/6/7/8205/52/21/6 (72.2/18.3/7.4/2.1)145/39/14/2 (72.5/19.5/7.0/1.0)60/13/7/4 (71.4/15.5/8.3/4.8)0.200
CP grade A (vs B)257 (90.5)184 (92.0)73 (86.9)0.182
ALBI score-2.48 [(-4.77)-(-1.14)]-2.45 [(-3.33)-(-1.61)]-2.55 [(-4.77)-(-1.14)]0.036a
ALBI grade 1/2/3104/179/1 (36.6/63.0/0.4)66/134/0 (33.0/67.0/0.0)38/45/1 (45.2/53.6/1.2)0.039a
MELD score4.87 [(-26.65)-18.60]4.55 [(-26.65)-18.60]5.85 [(-2.87)-17.80]0.001b
FIB-40.70 (0.12-9.29)0.62 (0.12-4.23)0.87 (0.17-9.29)0.001b
Antiviral treatment97 (34.2)43 (21.5)54 (64.3)< 0.001b
Pathological cirrhosis yes/no/censored85/168/31 (29.9/59.2/10.9)53/62.5/11.0 (26.5/62.5/11.0)32/43/9 (38.1/51.2/10.7)0.047a
Single/multiple HCC lesion(s)209/75 (73.6/26.4)142/58 (71.0/29.0)67/17 (79.8/20.2)0.125
Diameter of HCC lesion, cm5.75 (0.70-21.60)6.25 (0.70-21.60)4.00 (1.10-18.00)< 0.001b
Splenomegaly67 (23.6)44 (22.0)23 (27.4)0.330
Absent/slight/moderate or abundant ascites264/18/2 (93.0/6.3/0.7)187/12/1 (93.5/6.0/0.5)77/6/1 (91.7/7.1/1.2)0.762
Esophagogastric varices30 (10.6)14 (7.0)16 (19.0)0.003b
BCLC stage 0/A/B11/203/70 (3.9/71.5/24.6)6/138/56 (3.0/69.0/28.0)5/65/14 (6.0/77.4/16.7)0.082
2Emin, kPa7.90 (1.00-28.30)8.00 (1.00-25.10)7.50 (4.00-33.90)0.809
2Emean, kPa9.65 (1.00-33.90)9.70 (1.00-31.50)9.15 (4.00-33.90)0.453
2Emax, kPa12.00 (1.00-46.70)12.10 (1.00-38.00)11.45 (5.50-46.70)0.536
Table 2 Correlation between Emean with liver condition related index and liver enzymes
ParameterTotal
Pos group
Neg group

r
P value
r
P value
r
P value
CP score0.25< 0.001b0.25< 0.001b0.240.026a
CP grade0.21< 0.001b0.230.001b0.180.106
ALBI score0.31< 0.001b0.35< 0.001b0.270.012a
ALBI grade0.26< 0.001b0.24< 0.001b0.280.011a
MELD< 0.010.955-0.060.4320.110.308
TBIL0.180.002b0.170.016a0.230.038a
ALB-0.25< 0.001b-0.27< 0.001b-0.230.038a
PT0.33<0.001b0.39< 0.001b0.230.033a
ALT0.120.042a0.160.023a0.080.447
AST0.190.002b0.240.001b0.140.205
ALP0.26< 0.001b0.36< 0.001b0.080.447
Table 3 Correlation between Emean and liver condition with different alanine aminotransferase
ParameterPos group
Neg group
ALT ≤ 40 U/L, n = 122
ALT > 40 U/L, n = 78
ALT ≤ 40 U/L, n = 71
ALT > 40 U/L, n = 13

r
P value
r
P value
r
P value
r
P value
CP score0.220.016a0.230.044a0.310.009b0.230.447
CP grade0.20.030a0.210.0650.20.1020.230.447
ALBI score0.290.001b0.360.001b0.350.003b0.060.855
ALBI grade0.210.018a0.270.018a0.230.0540.390.182
MELD-0.060.508-0.080.480.180.1250.020.945
TBIL0.140.1270.130.2640.250.036a0.090.779
ALB-0.240.007b-0.290.009b-0.290.015a-0.10.817
PT0.43< 0.001b0.330.004b0.280.018a0.070.811
Table 4 Correlation between Emean and liver condition with different aspartate aminotransferase
ParameterPos group
Neg group
AST ≤ 37 U/L, n = 92

AST > 37 U/L, n = 108
AST ≤ 37 U/L, n = 61
AST > 37 U/L, n = 23

r
P value
r
P value
r
P value
r
P value
CP score0.060.5750.290.002b0.150.2520.30.161
CP grade0.080.4450.240.013a0.070.6120.220.321
ALBI score0.180.0870.33< 0.001b0.190.1350.280.200
ALBI grade0.090.4010.230.018a0.180.1770.410.055
MELD0.080.428-0.10.3210.040.7830.250.244
TBIL0.070.510.080.4420.150.2470.150.485
ALB-0.130.207-0.310.001b-0.160.211-0.260.228
PT0.270.009b0.35< 0.001b0.170.1860.190.380