Influence of nonalcoholic fatty liver disease on response to antiviral treatment in patients with chronic hepatitis B: A meta-analysis

Table 1 The basic characteristics of the enrolled studies included in this meta-analysis

Ref.		Ateş et al[8]	Jin et al[9]	Gong et al[10]	Liu et al[11]	Zhu et al[12]	Kim et al[13]	Cho et al[14]	Lee et al[15]	Chen et al[16]	Li et al[17]	Liang et al[18]
Year		2011	2012	2015	2015	2016	2019	2019	2019	2020	2020	2021
Location		Turkey	China	China	China	China	Korea	Korea	Korea	China	United States	China
Study		Prospective study	Prospective study	Prospective study	Prospective study	Retrospective study	Retrospective study	Retrospective study	Retrospective study	Retrospective study	Retrospective study	Prospective study
Journal		World J Gastroenterol	PLoS One	Transplant Proc	J Interferon Cytokine Res	Drug Des Devel Ther	Clin Mol Hepatol	J Clin Gastroenterol	Clin Mol Hepatol	BMC Gastroenterol	Liver Int	Gastroenterol Res Pract
Therapy regimen		PEG-IFN	Nucleos(t)ide analogues	PEG-IFN	Nucleos(t)ide analogues	Nucleos(t)ide analogues	Nucleos(t)ide analogues	Nucleos(t)ide analogues	Nucleos(t)ide analogues	Nucleos(t)ide analogues	Nucleos(t)ide analogues	PEG-IFN
Male	CHB with NAFLD	95	32	20	23	42	91	171	50	43	126	95
	CHB	82	85	38	12	41	119	333	146	43	211	82
Famale	CHB with NAFLD	12	33	11	17	19	69	89	20	13	61	12
	CHB	3	63	20	8	23	69	233	105	13	157	37
Age	CHB with NAFLD	50.5 ± 8.7	39.56 ± 11.87	30.3 ± 7.4	37.70 ± 7.90	39.26 ± 10.39	51.0 (42.0-56.3)	52.0 ± 9.4	45 (36–51)	39 (31-34)	47.7 ± 12.5	20.87 ± 1.96
	CHB	35.2 ± 8.9	39.55 ± 7.83	25.1 ± 7.8	37.35 ± 8.49	39.61 ± 10.87	51.0 (43.3-57.0)	54.0 ± 8.8	41 (32–48)	38.5 (31–44)	45.5 ± 14.6	29.50 ± 5.47
BMI	CHB with NAFLD	32.9 ± 3.1	26.35 ± 4.19	25.3 ± 2.1	28.16 ± 1.43	26.29 ± 3.99	24.7 (22.3-26.7	24.5 ± 3.5	NA	25.0 ± 3.0	25.4 ± 4.3	NA
	CHB	25.7 ± 3.3	24.26 ± 3.41	22.5 ± 2.9	22.06 ± 1.02	22.50 ± 2.85	22.5 (20.4-24.4)	23.8 ± 3.2	NA	23.0 ± 3.0	23.8 ± 4.0	20.87 ± 1.96
ALT	CHB with NAFLD	128.3 ± 18.9	143.3 ± 82.1	171.68 ± 46.23	227.70 ± 121.14	179.87 ± 78.50	56 (38-94)	NA	71 (32–114)	99 (68-154)	60 (15 - 1525)	NA
	CHB	139.2 ± 52.5	157.1 ± 108.3	159.18 ± 45.12	229.95 ± 137.36	187.95 ± 79.88	56 (34-90)	NA	94 (45–171)	124 (79–216)	50 (14 - 1079)	257.39 ± 175.17
AST	CHB with NAFLD	90.7 ± 34.8	70.2 ± 33.7	59.66 ± 13.81	183.23 ± 103.70	NA	NA	NA	53 (36–86)	61 (38-84)	37 (13 - 1465)	NA
	CHB	107.0 ± 40.3	93.5 ± 72.3	56.63 ± 13.13	167.60 ± 85.07	NA	NA	NA	85 (51–153)	72 (45–137)	35 (12 - 863)	126.72 ± 79.55
GGT	CHB with NAFLD	49.8 ± 29.8	95.2 ± 73.2	42.92 ± 14.83	98.75 – 19.90	NA	NA	NA	NA	NA	NA	NA
	CHB	50.0 ± 44.0	77.2 ± 89.7	46.05 ± 11.36	51.41 – 5.46	NA	NA	NA	NA	NA	NA	NA
TB	CHB with NAFLD	NA	NA	NA	NA	NA	0.8 (0.7-1.1)	1.0 ± 0.4	NA	0.8 (0.6-1.0)	1.3 ± 3.0	NA
	CHB	NA	NA	NA	NA	NA	0.9 (0.7-1.2)	1.1 ± 0.4	NA	1.0 (0.7–1.2)	1.3 ± 2.7	NA
ALB	CHB with NAFLD	NA	NA	NA	NA	NA	4.2 (4.0-4.4)	4.18 ± 0.3	4.2 (3.8–4.4)	NA	4.0 ± 0.6	NA
	CHB	NA	NA	NA	NA	NA	4.2 (3.9-4.4)	4.25 ± 0.4	4.0 (3.7–4.3)	NA	3.9 ± 0.6	NA
TC	CHB with NAFLD	192.2 ± 28.0	84.6 ± 14.4	80.28 ± 7.92	115.02 ± 9	68.04 ± 1.26	178 (151-204)	NA	176 (155–203)	NA	181 ± 40	NA
	CHB	178.0 ± 27.4	81.0 ± 14.4	78.66 ± 5.76	81.18 ± 8.1	66.96 ± 17.46	170 (151-190)	NA	159 (137–179)	NA	177 ± 41	0.56 ± 0.45
TG	CHB with NAFLD	188.3 ± 52.0	34.2 ± 14.4	27.54 ± 6.84	48.06 ± 10.98	32.4 ± 16.2	NA	NA	103 (81–137)	NA	189 ± 153	NA
	CHB	114.2 ± 44.2	21.6 ± 9	19.98 ± 7.02	25.92 ± 2.88	23.94 ± 11.52	NA	NA	80 (63–109)	NA	86 ± 42	4.68 ± 0.80
HDL	CHB with NAFLD	NA	NA	NA	NA	15.48 ± 6.12	NA	NA	44.4 (35.4–54.4)	NA	40 ± 9	NA
	CHB	NA	NA	NA	NA	19.26 ± 6.3	NA	NA	48.3 (39.4–59.4)	NA	58 ± 19	NA
LDL	CHB with NAFLD	NA	NA	NA	NA	41.58 ± 12.96	113 (93-129)	NA	105 (87–129)	NA	111 ± 37	NA
	CHB	NA	NA	NA	NA	38.88 ± 12.24	101 (80-126)	NA	90 (75–108)	NA	106 ± 32	NA
Glucose	CHB with NAFLD	102.7 ± 27.7	4.8 ± 0.6	5.46 ± 1.37	NA	5.11 ± 0.85	96.0 (89.3-107.0)	NA	103 (92–117)	NA	115 ± 37	NA
	CHB	96.7 ± 19.0	4.5 ± 0.5	5.07 ± 0.92	NA	4.89 ± 0.80	9 4.0 (87.3-102)	NA	98 (90–108)	NA	105 ± 26	NA
Quality scores		6	7	7	6	6	7	8	6	7	6	6

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; TC: Total cholesterol; TG: Triglyceride; TB: Total bilirubin; ALB: Albumin; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; NA: Not available.