Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2024; 16(3): 465-476
Published online Mar 27, 2024. doi: 10.4254/wjh.v16.i3.465
Influence of nonalcoholic fatty liver disease on response to antiviral treatment in patients with chronic hepatitis B: A meta-analysis
Shi-Yi Liu, Dian Wang, Jing Liu, Lu-Ping Yang, Gong-Ying Chen
Shi-Yi Liu, Lu-Ping Yang, Department of Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Dian Wang, Department of Medicine, Hangzhou Normal University, Hangzhou 310011, Zhejiang Province, China
Jing Liu, Gong-Ying Chen, Department of Infectious and Hepatology Diseases, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Co-first authors: Shi-Yi Liu and Dian Wang.
Author contributions: Liu SY and Wang D reviewed each article independently; Data were extracted from studies meeting both inclusion and exclusion criteria following a review of the entire contents of each paper; Chen GY as a third investigator, discussion, or revision to resolve any differences.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gong-Ying Chen, MD, Professor, Department of Infectious and Hepatology Diseases, Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Hangzhou 310015, Zhejiang Province, China. liuxingli0329@163.com
Received: October 24, 2023
Peer-review started: October 24, 2023
First decision: January 5, 2024
Revised: January 26, 2024
Accepted: February 28, 2024
Article in press: February 28, 2024
Published online: March 27, 2024
Core Tip

Core Tip: No consensus is available in the literature about which effect of nonalcoholic fatty liver disease on the response to antiviral treatment in patients with chronic hepatitis B (CHB). This is a systematic review and meta-analysis comparing the response to antiviral treatment between patients with CHB only and those with CHB and hepatic steatosis were included. We investigated these two groups in terms of biochemical responses, serological responses, virological responses the incidence of hepatocellular carcinoma.