Recent advances in the diagnosis of drug-induced liver injury

Table 1 Differences between The Roussel Uclaf Causality Assessment Method and revised electronic causality assessment method scores

RUCAM	RECAM
Criteria 1: Latency	Domain 1a: Latency from drug start
	Domain 1b: Latency from drug stop
Criteria 2: Dechallenge	Domain 2: Dechallenge
Different time cut-offs based on R value	Same time cut-offs regardless of R value
Criteria 3: Risk factors	Eliminated
Criteria 4: Concomitant drugs	Domain 3: Literature supporting drug toxicity (LiverTox)
Criteria 5: Exclusion of non-drug etiologies	Domain 4: Exclusion of non-drug etiologies
Criteria 6: Known hepatotoxicity of drug	Became domain 3
Criteria 7: Rechallenge response	Domain 5: Rechallenge response - both prospectively documented with lab testing and retrospective based on patient history. Includes additional data: Liver biopsy results, atypical viral testing, and presence of severe skin reactions

RUCAM: The Roussel Uclaf Causality Assessment Method; RECAM: Revised electronic causality assessment method.