Diagnostic value of tissue plasminogen activator-inhibitor complex in sepsis-induced liver injury: A single-center retrospective case-control study

Table 1 Demographic characteristics of sepsis patients with or without liver injury

Characteristics	Normal range	Total (n = 546)	Sepsis (n = 373)	SILI (n = 173)	P value
Age, year, median (IQR)	-	65 (51-81)	66 (50.5-81.5)	63 (51-76)	0.166
Male, n (%)	-	380 (69.6)	258 (69.2)	122 (70.5)	0.749
WBC, × 109/L, median (IQR)	3.5-9.5	11.0 (7.9-15.2)	10.8 (7.7-14.6)	12.1 (8.2-16.4)	0.047
RBC, × 1012/L, mean ± SD	3.8-5.1	3.4 ± 0.9	3.4 ± 0.9	3.5 ± 1.1	0.212
HGB, g/L, mean ± SD	115-150	103.7 ± 28.9	103.3 ± 27.3	104.7 ± 32.0	0.624
Platelet, × 109/L, median (IQR)	125-350	163.5 (109.8-230.3)	172.0 (124.0-237.5)	136.0 (73.0-215.5)	< 0.001
ALT, U/L, median (IQR)	0-40	26.8 (14.2-60.7)	18.6 (12.0-32.4)	98.0 (42.4-217.7)	< 0.001
AST, U/L, median (IQR)	8-40	37.3 (20.9-75.1)	27.1 (18.7-42.8)	116.8 (74.6-333.2)	< 0.001
TBIL, mmol/L, median (IQR)	3.42-20.5	13.3 (7.8-24.4)	10.4 (6.8-16.4)	35.0 (14.7-63.4)	< 0.001
Albumin, g/L, mean ± SD	38-51	31.9 ± 6.8	33.0 ± 6.6	29.4 ± 6.6	< 0.001
Cr, mmol/L, median (IQR)	44-80	84.2 (59.9-152.0)	76.1 (56.0-118.8)	110.1 (73.4-193.8)	< 0.001
CRP, mg/L, median (IQR)	0-5	41.2 (8.5-100.2)	34.1 (8.3-85.6)	53.9 (11.2-117.8)	0.003
Lac, mmol/L, median (IQR)	0.5-1.6	1.7 (1.0-3.6)	1.4 (0.9-2.7)	3.2 (1.7-5.5)	< 0.001
PT, s, median (IQR)	10-14	14.3 (12.9-16.4)	13.9 (12.7-15.4)	15.4 (13.6-19.6)	< 0.001
APTT, s, median (IQR)	22-38	31.2 (26.8-36.9)	30.4 (26.6-35.4)	33.5 (27.7-41.5)	< 0.001
FIB, g/L, median (IQR)	2-4.5	2.7 (1.8-3.5)	2.8 (2.0-3.6)	2.3 (1.5-3.3)	< 0.001
TT, s, median (IQR)	10-16	16.1 (14.7-17.9)	15.7 (14.5-17.4)	17.4 (15.2-19.6)	< 0.001
FDP, mg/L, median (IQR)	0-5	7.5 (3.1-19.3)	5.9 (2.5-14.6)	13.0 (5.5-31.8)	< 0.001
D-dimer, mg/L, median (IQR)	0-0.5	2.5 (1.0-6.1)	2.0 (0.8-4.8)	4.2 (1.7-9.4)	< 0.001
TM, TU/mL, median (IQR)	3.82-13.35	10.8 (7.7-16.9)	10.0 (7.3-14.5)	13.3 (9.3-23.1)	< 0.001
TAT, ng/mL, median (IQR)	0-4.07	10.1 (4.6-29.1)	7.5 (4.0-20.4)	18.4 (7.5-53.3)	< 0.001
t-PAIC, ng/mL, median (IQR)	Female: 0-10.5. Male: 0-17.0	12.2 (7.4-18.9)	9.8 (5.9-14.4)	20.6 (14.9-29.9)	< 0.001
PIC, μg/mL, median (IQR)	0-0.85	1.3 (0.7-2.4)	1.2 (0.7-2.1)	1.6 (0.7-3.3)	0.021
GCS score, median (IQR)	15	8 (4-12)	9 (5-12)	7 (3-12)	0.032
APACHE II score, median (IQR)	0	21 (16-27)	20 (16-26)	23 (18-28)	0.001
Child-Pugh score, median (IQR)	5	8 (7-9)	7 (7-8)	9 (8-11)	< 0.001

SILI: Sepsis-induced liver injury; IQR: Interquartile range; WBC: White blood cell; RBC: Red blood cell; HGB: Hemoglobin; ALT: Alanine transaminase; AST: Aspartate transaminase; TBIL: Total bilirubin; Cr: Creatinine; CRP: C-reaction protein; Lac: Lactate; PT: Prothrombin time; APTT: Activated partial thrombin time; FIB: Fibrinogen; TT: Thrombin time; FDP: Fibrinogen degradation product; TM: Thrombomodulin; TAT: Thrombin-antithrombin complex; t-PAIC: Tissue plasminogen activator-inhibitor complex; PIC: α2-plasmin inhibitor-plasmin complex; GCS: Glasgow Coma Scale; APACHE II: Acute physiological and chronic health evaluation II.