Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Nov 27, 2024; 16(11): 1255-1264
Published online Nov 27, 2024. doi: 10.4254/wjh.v16.i11.1255
Diagnostic value of tissue plasminogen activator-inhibitor complex in sepsis-induced liver injury: A single-center retrospective case-control study
Ye Zhou, Long-Ping He, Ying-Han Qi, Yu Huang, Bing-Qin Hu, Jia-Ling Liu, Qing-Bo Zeng, Jing-Chun Song
Ye Zhou, Long-Ping He, Ying-Han Qi, Yu Huang, Bing-Qin Hu, Jia-Ling Liu, Jing-Chun Song, Department of Critical Care Medicine, Changcheng Hospital Affiliated to Nanchang University, Nanchang 330002, Jiangxi Province, China
Ye Zhou, Jing-Chun Song, Department of Critical Care Medicine, The 908th Hospital of Chinese People’s Liberation Army Joint Logistic Support Force, Nanchang 330002, Jiangxi Province, China
Qing-Bo Zeng, Intensive Care Unit, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang 330002, Jiangxi Province, China
Author contributions: Zhou Y drafted the manuscript; Zhou Y, He LP, and Zeng QB contributed to the statistical analysis; He LP, Qi YH, Huang Y, Hu BQ, and Liu JL participated in the acquisition of data; Song JC revised the manuscript. All authors read and approved the final manuscript.
Supported by National Key R&D Program of China, No. 2022YFC2304600.
Institutional review board statement: This study was approved by the Ethics Committee of the 908th Hospital of Chinese People’s Liberation Army Joint Logistic Support Force, No. 908yyLL028.
Informed consent statement: As patients or their legal guardians signed a written consent form upon admission, agreeing to disclose their anonymous medical data for research purposes, no informed consent was required for this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Chun Song, MD, PhD, Chief Physician, Department of Critical Care Medicine, Changcheng Hospital Affiliated to Nanchang University, No. 1028 Jinggangshan Road, Nanchang 330002, Jiangxi Province, China. songjingchun@126.com
Received: April 14, 2024
Revised: September 5, 2024
Accepted: October 15, 2024
Published online: November 27, 2024
Processing time: 206 Days and 1.5 Hours
Core Tip

Core Tip: Our study showed that tissue plasminogen activator-inhibitor complex levels were significantly higher in patients with sepsis-induced liver injury and differed significantly between patients with different severity of liver dysfunction. Furthermore, our study proposed that tissue plasminogen activator-inhibitor complex may be an effective biomarker for diagnosis of sepsis-induced liver injury, providing a novel tool for its clinical recognition.