Revolution in the diagnosis and management of hepatitis C virus infection in current era

Table 1 Summary of the main trials of various directly acting antivirals in the treatment of chronic hepatitis C virus infection

reported lower incidence of HCC with DAAs as compared to untreated patients (2.90 and 4.48per 100 person-years, respectively). Moreover, Romano

Trial Names	Regimens	Treatment experienced /naive	Genotype	Duration	Cirrhotics/non-cirrhotics	SVR12, %
TARGET	Sofosbuvir-Ribavirin	Naïve	2	12 wk	Cirrhotics	91.9
					Non-cirrhotics	71.9
			3		Cirrhotics	75
					Non-cirrhotics	55.3
ASTRAL 2 and ASTRAL 3	Sofosbuvir-Ribavirin	Naïve	3	24 wk	Cirrhotics	73.3
					Non-cirrhotics	90.4
ION 1	Sofosbuvir-Ledipasvir	Naïve	1	24 wk	Cirrhotics	96.9
					Non-cirrhotics	99.5
TURQUOISE-III	Ombitasvir-Paritasprevir- Ritonavir	Naïve	1b	12 wk	Cirrhotics	100
ASTRAL 3	Sofosbuvir- Velpatasvir	Naïve	3	12 wk	Cirrhotics	93
					Non-cirrhotics	98.2
		Treatment Experienced		12 wk	Cirrhotics	89.2
					Non-cirrhotics	91.2
ASTRAL 4	Sofosbuvir- Velpatasvir-Ribavarin	Naïve	1	12 wk	Cirrhotics	94.4
		Treatment Experienced				90
ASTRAL 4	Sofosbuvir- Velpatasvir-Ribavarin	Naïve	3	12 wk	Cirrhotics	84.6
		Treatment Experienced				96.2
POLARIS 2	Sofosbuvir-Velpatasvir-Voxilaprevir	Naïve	1-6	8 wk	Cirrhotics	91
					Non-cirrhotics	96
POLARIS 3	Sofosbuvir-Velpatasvir-Voxilaprevir	Naïve	3	8 wk	Cirrhotics	96.3
		Treatment Experienced				97